This study explored, the inflammatory response during experimental pneumonia in surfactant-depleted animals as a function of ventilation strategies and surfactant treatment. Following intratracheal instillation of Group B streptococci (GBS), surfactant-depleted piglets were treated with conventional (positive-end expiratory pressure (PEEP) of 5 cmH2O, tidal volume 7 mL x kg(-1)) or open lung ve...

Background: Neonatal respiratory-distress syndrome (nRDS) is a disease that affects the lung functions in premature infants who are born before their surfactant biosynthetic system has matured. Several surfactant-replacement therapies have been developed and are efficacious in treating the RDS. Objective: The study investigates the inflammatory response of the lung derived cells in rat pups wit...

PURPOSE To study the immunogenicity and the stability of the porcine pulmonary surfactant preparation produced by the Instituto Butantan. METHOD Immunogenicity assay: Sixteen New-Zealand-White rabbits (1000 g body weight) were divided into 4 study groups. Each group was assigned to receive either a) Butantan surfactant, b) Survanta (Abbott Laboratories), c) Curosurf (Farmalab Chiesi), or d) n...

The effect of uncharged surfactant additives on the oppositely charged polyion/ionic surfactant complexation is usually described as a direct equilibrium association between the polyelectrolyte molecules and free mixed micelles analogous to the polyion/colloidal particle interactions. This approach predicts that the binding of the ionic surfactant to the polyelectrolyte molecules can be complet...

The aim of this study was to investigate whether intratracheal administration of a new synthetic surfactant that includes the cationic, hydrophobic 21-residue peptide KLLLLKLLLLKLLLLKLLLLK (KL₄), might be effective in reducing ischaemia-reperfusion injury after lung transplantation. Single left lung transplantation was performed in Landrace pigs 22 h post-harvest. KL₄ surfactant at a dose of 25...

Alternative methods for determining the critical micelle concentration (cmc) are investigated using canonical and grand canonical Monte Carlo simulations of a lattice surfactant model. A common measure of the cmc is the "free" (unassociated) surfactant concentration in the presence of micellar aggregates. Many prior simulations of micellizing systems have observed a decrease in the free surfact...

AIMS To investigate the incidence of acute and cicatricial retinopathy of prematurity (ROP) in a cohort of premature neonates entered into a randomised, multicentre trial of prophylactic exogenous surfactant for respiratory distress syndrome (RDS) compared with controls receiving surfactant only if severe RDS developed. METHODS The incidence of acute and cicatricial ROP was assessed in 304 ne...

In addition to providing mechanical stability, growing evidence suggests that surfactant lipid components can modulate inflammatory responses in the lung. However, little is known of the molecular mechanisms involved in the immunomodulatory action of surfactant lipids. This study investigates the effect of the lipid-rich surfactant preparations Survanta, Curosurf, and the major surfactant phosp...

Surfactant has been shown to inhibit the production of reactive oxygen intermediates by various cells including alveolar macrophages and peripheral blood neutrophils. Superoxide O2-. production by the respiratory burst oxidase in isolated plasma membranes prepared from PMA-treated human neutrophils was significantly attenuated by prior treatment with native porcine surfactant. The effect was co...

experiments were conducted to study the ability of surfactant-modified clinoptilolite for molybdate adsorption from aqueous solutions. clinoptilolite was treated with some cationic surfactants. adsorption of surfactants on zeolite surface was confirmed by chemical analysis, ir (infra-red spectroscopy), dtg (derivative thermogravimetry) and sem (scanning electron microscopy) techniques. the modi...