Clonidine is an effective preanesthetic medication in children, providing a preoperative sedative effect. The analgesic properties of the drug have been well documented in adults. The current study was designed to investigate the effect of oral clonidine given preoperatively on postoperative pain in children undergoing minor surgery. In a prospective, randomized, controlled clinical trial, 90 c...

Spectrophotometric method is often recommended in dissolution testing of not only tablets or capsules but also suppositories. Dissolution rate of diclofenac sodium was studied using a pharmacopoeial flow-through apparatus and pH 7.3 buffer. For two lipophilic suppository bases (Witepsol W-32 and H-19) dissolution rate was overestimated with the spectrophotometric zero-order method in comparison...

A study was undertaken to investigate recent reports concerning the use of transcutaneous electrostimulation (TES) for relief of postoperative pain. Thirty patients undergoing elective herniorrhaphy were subjected to a standard perianaesthetic protocol. The patients were divided into three groups of ten, designated control, sham TES and TES. Postoperative analgesic requirements for each group w...

Objective: The aim of this study was to compare the postoperative analgesic effects of preoperative intravenous (i.v.) paracetamol, diclofenac sodium and lornoxicam (nonsteroidal anti-inflammatory drugs). Subjects and Methods: Sixty patients with impacted third molar who underwent surgical removal were randomly allocated into three groups: group P (n = 20), group D (n = 20) and group L (n = 20)...

To the Editor: Meperidine, also known as pethidine, is one of the most commonly prescribed opioid analgesics. Meperidine exerts high central nervous system depressant effects through producing prolonged activation of opioid receptors (μ‐receptor). We described a rare case of generalized tonic–clonic seizures after intravenous (IV) injection of meperidine for bronchoscopy premedication in a pati...

Objective: The aim of this study was to compare the postoperative analgesic effects of preoperative intravenous (i.v.) paracetamol, diclofenac sodium and lornoxicam (nonsteroidal anti-inflammatory drugs). Subjects and Methods: Sixty patients with impacted third molar who underwent surgical removal were randomly allocated into three groups: group P (n = 20), group D (n = 20) and group L (n = 20)...

purpose: to evaluate the efficacy of pretreatment with diclofenac sodium 1% eye drop for prevention of post-cataract surgery ocular inflammation. methods: a double blind clinical trial was performed on 111 patients who were scheduled for phacoemulsification and intraocular lens implantation (pe+iol) at feiz hospital, isfahan-iran. cases with traumatic cataract and complicated surgery were exclu...

Objective: The aim of this study was to compare the postoperative analgesic effects of preoperative intravenous (i.v.) paracetamol, diclofenac sodium and lornoxicam (nonsteroidal anti-inflammatory drugs). Subjects and Methods: Sixty patients with impacted third molar who underwent surgical removal were randomly allocated into three groups: group P (n = 20), group D (n = 20) and group L (n = 20)...

objective: t o evaluate the effects of intravenous ketorolac on early postoperative pain in patients with mandibular fractures, who underwent surgical repair. methods: this prospective, randomized, placebo-controlled clinical trial was conducted in shahid rajaei hospital, affiliated with shiraz university of medical sciences during a 1-year period from 2015 to 2016. we included a total number o...