Superparamagnetic iron oxide nanoparticles (SPIONs) bound directly to luteinizing hormone releasing hormone (LHRH) have shown high efficiency for intracellular uptake to breast cancer cells, MDA-MB-435S.luc. We demonstrate in this communication that inclusion of a small spacer molecule such as glutaric acid (Glu) in between SPION and LHRH increases further receptor mediated intracellular uptake...

The MIAplex® device is a miniaturized detector, devoted to the high sensitive detection of superparamagnetic nanoprobes for multiparametric immunoassays. It measures a signal corresponding to the second derivative of the magnetization around zero field. Like any new technology, the real success of the MIAplex® detector can only be exploited through a deep understanding of the magnetic signature...

Recently, multifunctional magnetic nanostructures have been found to have potential applications in biomedical and tissue engineering. Iron oxide nanoparticles are biocompatible and have distinctive magnetic properties that allow their use in vivo for drug delivery and hyperthermia, and as T2 contrast agents for magnetic resonance imaging. Hydroxyapatite is used frequently due to its well-known...

A straightforward route is proposed for the multi-gram scale synthesis of heterobifunctional poly(ethylene glycol) (PEG) oligomers containing combination of triethyloxysilane extremity for surface modification of metal oxides and amino or azido active end groups for further functionalization. The suitability of these PEG derivatives to be conjugated to nanomaterials was shown by pegylation of u...

Background Recently, we could demonstrate in humans that (ultrasmall) superparamagnetic iron-oxide (U/SPIO)-based contrast agents enable a detailed characterization of myocardial infarct pathology. Considering the multifunctionality of U/SPIO-based nanoparticles (magnetic targeting as well as diagnostic imaging properties) and their superior safety profile compared to gadoliniumbased compounds,...

International Nonproprietary Name (INN): superparamagnetic iron oxide nanoparticles stabilised with dextran and sodium citrate Day 180 Assessment Report as adopted by the CHMP with all information of a commercially confidential nature deleted. This should be read in conjunction with the " Question and Answer " document on the withdrawal of the application: the Assessment Report may not include ...

The ability of mesenchymal stem cells (MSC) to specifically home to tumors has suggested their potential use as a delivery vehicle for cancer therapeutics. MSC integration into tumors has been shown in animal models using histopathologic techniques after animal sacrifice. Tracking the delivery and engraftment of MSCs into human tumors will need in vivo imaging techniques. We hypothesized that l...