This article provides an overview on the development of integrated multifunctional nanosystems for medical diagnosis and treatment. In particular, a novel system is developed specifically for achieving simultaneous diagnosis and treatment of cancer. Critical issues are addressed on the architecture and assembly of nanocomponents based on medical requirements: targeted in vivo imaging, controlle...

Cerebral blood flow (CBF) during stepped hypercapnia was measured simultaneously in the rat brain using near-infrared diffuse correlation spectroscopy (DCS) and arterial spin labeling MRI (ASL). DCS and ASL CBF values agree very well, with high correlation (R=0.86, p< 10(-9)), even when physiological instability perturbed the vascular response. A partial volume effect was evident in the smaller...

The interest in MRI methods that are capable of non-invasively measuring the microvascular structure of tumors has grown steadily over the past years [1,2]. As shown in a previous work, we have developed an approach to joint blood volume and vessel size assessment via simultaneous R2 and R2* quantification pre and post injection of a super-paramagnetic blood pool agent [3]. Preclinical studies ...

Introduction: Magnetic particle imaging (MPI) is a new tomographic method [1] based on the nonlinear response of super-paramagnetic iron oxide (SPIO) nanoparticles. It has promise for fast imaging in the submillimeter range with some advantages in sensitivity, contrast, and cost in comparison with MRI. A static but spatially inhomogeneous field (selection field) and homogeneous oscillating fiel...

Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites in mice. To achieve...

The bond lifetime-force behavior of the immunoglobulin G (IgG)-protein A interaction has been studied with magnetic tweezers to characterize the physical properties of the bond under nonequilibrium conditions. Super-paramagnetic microparticles were developed that have a high and uniform magnetization to simultaneously apply a piconewton-scale tensile force to many thousands of IgG-protein A bon...

This study explored the imaging capability of our frequency-domain photoacoustic (FD-PA) system that utilizes correlation processing alias “photoacoustic radar” and ultrasonic phased array for imaging of soft tissues. The probe imaging capabilities were studied using tissuemimicking phantoms, tissue samples ex vivo, blood vessels in a human wrist and a rat tumour model in vivo. Our experimental...

objective(s):iron oxide nanoparticles have found prevalent applications in various fields including drug delivery, cell separation and as contrast agents. super paramagnetic iron oxide (spio) nanoparticles allow researchers and clinicians to enhance the tissue contrast of an area of interest by increasing the relaxation rate of water. in this study, we evaluate the dependency of hydrodynamic si...

introduction: apoptosis is a major consequence of ionizing radiation in proliferative tissues and quantification of the apoptotic cells could be helpful for noninvasive assessment and estimation of the radiation absorbed dose. annexin v conjugated with super paramagnetic iron oxide nanoparticles (anx-spio) is a biological probe for detection of apoptotic cells using magnetic resonance imaging. ...

We use super-paramagnetic colloidal particles confined by gravitation to a flat water-air interface as a model system to study the non-equilibrium liquid-solid phase transition in two dimensions. The system temperature is adjustable by changing the strength of an external magnetic field perpendicular to the water-air interface. Increasing the magnetic field on a timescale of milliseconds quench...