There is compelling evidence that serum, tissue and intracellular levels of copper are elevated in all types of cancer. Copper has been suggested as an important co-factor for angiogenesis. It is also a major metal ion present inside the nucleus, bound to DNA bases, particularly guanine. We have earlier proposed that the interaction of phenolic-antioxidants with intracellular copper leads to th...

The CRR1 (Copper Response Regulator) locus, required for both activating and repressing target genes of a copper- and hypoxia-sensing pathway in Chlamydomonas, encodes a 1,232-residue candidate transcription factor with a plant-specific DNA-binding domain named SBP, ankyrin repeats, and a C-terminal Cys-rich region, with similarity to a Drosophila metallothionein. The recombinant SBP domain of ...

The measurement of combined copper has been used in a number of procedures for the quantitative determination of amino acids and peptides. Pope and Stevens (1) as well as Schroeder, Kay, and Mills (2) determined the combined copper iodometrically. Martin and Mittelmann (3) analyzed for copper with the polarograph. Woiwod (4) used the spectrophotometer to measure the color produced by the reacti...

Arbuscular mycorrhizal (AM) fungi establish a mutualistic symbiosis with the roots of most plant species. While receiving photosynthates, they improve the mineral nutrition of the plant and can also increase its tolerance towards some pollutants, like heavy metals. Although the fungal symbionts exclusively colonize the plant roots, some plant responses can be systemic. Therefore, in this work a...

In this work the physiological effect of copper excess on the peach rootstock MrS 2/5 and GF 677 was studied by means of an in vitro system. Two different copper treatments (10 and 100 μM CuSO4) for each rootstock were carried out and compared to a control containing 0.1 μM of CuSO4. Relative growth rate and copper concentration inside rootstock tissues were measured after 21 days from the begi...

The aim of this study was to identify the effect of Spermine and Salicylic acid on several growth parameters, such as shoot length, shoot fresh and dry weights, amount of protein and carbohydrate, of Badami and Qazvini pistachio cultivated variety under copper stress. The experiment design was completely randomized with three replicates per treatment and four levels of copper (o.5, 30, 45, 60 µ...

Metals and polycyclic aromatic hydrocarbons (PAHs) are known to be toxic to plants. Because metals and PAHs often are cocontaminants in the environment, plants can be subjected to damage caused by their combined effects. We recently found that copper and an oxygenated PAH (1,2-dihydroxyanthraquinone [1,2-dhATQ]) synergistically are toxic to plants. This synergistic toxicity was linked indirectl...

An extensive review of Wisconsin Veterinary Diagnostic Laboratory(WVDL) accessions along with the results of slaughter house surveys indicate that copper is accumulating in the livers of Wisconsin Holsteins of all ages. Two hundred eleven WVDL accessions were reviewed based on breed(Holstein), age and results of inductively coupled plasma-mass spectroscopy(ICP-MS) liver element testing. The ove...

In large open pit mines prediction of Peak Particle Velocity (PPV) provides useful information for safe blasting. At Sungun Copper Mine (SCM), some unstable rock slopes facing to valuable industrial facilities are both expose to high intensity daily blasting vibrations, threatening their safty. So, controlling PPV by developing accurate predictors is essential. Hence, this study proposes improv...