This study aimed to evaluate 50 different cheese samples in terms of certain microbiological parameters. The presence Salmonella spp. and Listeria cheeses were investigated by immunomagnetic separation conventional methods. Staphylococcus aureus was detected 4 samples, while 2 accepted suspicious 5/50 found positive with respect isolates determined as Proteus mirabilis. Therefore, not from the ...

The antimicrobial drug susceptibilities of 145 isolates of Kingella kingae to eight antibiotics were determined by the disc diffusion method. In addition, penicillin MICs were determined by the Etest. Study isolates included 37 from blood, 34 from the skeletal system and 74 from respiratory carriers. All isolates were beta-lactamase negative and susceptible to erythromycin, gentamicin, chloramp...

A simple, fast and precise high performance liquid chromatographic method for the assay of trimethoprim in the presence of sulphamethoxazole has been developed. The procedure is based on using acetonitril: water: acetic acid in the ratio of 30:69.9:0.1 (v : v : v) as a mobile phase, flow rate (1ml/min.) and uv detector (254nm.).Each analysis required no longer than 10 minutes. the detector resp...

Penicillin is still satisfactory as the main treatment for gonorrhoea in Uganda, but there is evidence that its usefulness is declining. In 1961, there was a treatment failure rate of only 4 per cent. with a single dose of 0-3 mega units penicillin aluminium mono-stearate (PAM) (Kibukamusoke, 1965); four times that dose-1V2 mega units-gave a failure' rate of 17-9 per cent. in 1966 (Arya, unpubl...

The activity of trimethoprim (TMP) and sulphamethoxazole (SMX), alone and in combination, against a sensitive strain of Escherichia coli was investigated in turbidimetric systems. In a static system in which the conditions of exposure of bacteria to drug resembled those of conventional minimum inhibitory concentration (MIC) titrations, both TMP and SMX exhibited antibacterial activity at concen...

Patient compliance and drug efficacy and side-effects were compared in two groups of patients with symptoms of acute lower urinary tract infections. One group was treated with trimethoprim, one tablet (300 mg) once a day, and the other with co-trimoxazole, two tablets (160 mg trimethoprim, 800 mg sulphamethoxazole) twice a day; both treatments were prescribed for seven days. Patient compliance ...

To study the association of multidrug-resistant enteroaggregative Escherichia coli with persistent diarrhea in Kenyan children, stool specimens were obtained from 862 outpatients under 5 years of age from July 1991 to June 1993. E. coli O44 was identified as the sole bacterial pathogen in four patients experiencing at least 14 days of fever, vomiting, and diarrhea. Disk diffusion testing showed...

Diminished survival of transfused platelets occurred in two patients given co-trimoxazole, and a third patient taking this drug developed thrombocytopenia. By means of an indirect immunofluorescence assay antibodies against donor platelets coated with co-trimoxazole were found in the sera in all cases. These antibodies were directed against the trimethoprim component of co-trimoxazole and not a...

A 24-year-old female with Hodgkin's disease and Pneumocystis carinii pneumonia was tested with trimethoprim/sulphamethoxazole (TMP/SMX) tablets. Because treatment failure was feared owing to chronic emesis potentially resulting in incomplete drug absorption, the same TMP/SMX dose was administered by rectal suppositories after the 5th day of oral dosing. The relative fractions (rectal/oral) or t...

Seventy-two men with gonococcal urethritis were given a single 300-mg dose of minocycline. The failure rate was 13% and the trial was terminated at an early stage. Failure was correlated with increased resistance of Neisseria gonorrhoeae to minocycline. The activity of penicillin, spectinomycin, erythromycin, tetracycline, sulphamethoxazole, cefuroxime, cefotaxime, rosamicin, thiamphenicol, and...