Even though the addition of silver sulfadiazine (AgSu) to purified deoxyribonucleic acid (DNA) results in the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. AgSu blocked macromolecular syntheses in treated bacteria, DNA synthesis being slightly more sensitive to this inhibitory action. The ribosomes, ribonucleic acid, and DNA isolated from treate...

Chronic wounds represent a large and growing segment of health care and add considerably to human suffering and economic burden as populations age. More effective materials, especially those promoting ease of use and economy, are needed to treat this increasing number of patients. A case series conducted at a European outpatient tertiary wound centre used a novel surfactant-based biomaterial dr...

The objective of this study was to analyze which materials and methods are used for the management of partial and full thickness burns, as well as donor sites. An Internet survey was used to poll directors of burn centers around the world on their preferences for local treatment of different types of burns and donor sites. Results were tabulated and expressed as a percentage of the total number...

The antagonism of para-aminobenzoic acid (PABA) to the chemotherapeutic action of sulfonamides in vitro and in vivo has long been established by various workers (McCarty, 1941; Selbie, 1940; Thomas and Dingle, 1942; Woods, 1940). The studies of Woods and Fildes (Fildes, 1940; Woods, 1940; Woods and Fildes, 1940) provided, furthermore, a hypothetical picture of the metabolism of bacteria, based ...

Abstract Objective : Burns has become a global health problem because it causes about 180.000 deaths worldwide every year. In developing countries, silver sulfadiazine cream is usually used as drug management for second-degree burns, but expensive, so several herbal treatments have developed recently. The seed of edamame genistein compounds that can increase collagen synthesis. antioxidant comp...


 Purpose: To prepare, characterize and investigate the stability drug release profile of silver sulfadiazine (AgSD) nanoliposomes as functions pH, UV exposure, and/or heat.
 Methods: Silver were prepared. The properties free nanoliposomal formulations AgSD heat analyzed. analyses performed at different time points.
 Results: results characterization showed that acidic, basic neu...

Granulomatous amoebic encephalitis (GAE) due to Acanthamoeba is almost a uniformly fatal infection in immune-compromised hosts despite multidrug combination therapy. We report a case of GAE in a female who received a deceased donor kidney graft. She was treated with a combination of miltefosine, pentamidine, sulfadiazine, fluconazole, flucytosine, and azithromycin.

We conducted a retrospective study of AIDS-associated cerebral toxoplasmosis. Eighteen patients received pyrimethamine plus sulfadiazine and 25 co-trimoxazole, with comparable baseline characteristics. There were no differences in clinical outcomes, but co-trimoxazole was better tolerated (p = 0.066). There was also a trend towards more deaths among patients who received glucocorticoids.

The anti-Toxoplasma activities of nine antiretroviral drugs were examined in vitro. Nucleoside analogs had no effect on parasite growth, whereas ritonavir and nelfinavir were inhibitory for Toxoplasma, with 50% inhibitory concentrations of 5.4 and 4.0 microg/ml, respectively. None of the antiviral drugs affected the anti-Toxoplasma activity of pyrimethamine or sulfadiazine.