BACKGROUND Antiretroviral therapy (ART) partially corrects immune dysfunction associated with HIV infection. The levels of T-cell immune activation and exhaustion after long-term, suppressive ART and their correlation with CD4 T-cell count reconstitution among ART-treated patients in African cohorts have not been extensively evaluated. METHODS T-cell activation (CD38+HLA-DR+) and immune exhau...

OBJECTIVE To determine whether the preoperative lymphocyte-monocyte ratio (LMR) is a predictor of suboptimal cytoreduction in advanced-stage epithelial ovarian cancer (EOC). METHODS Preoperative clinico-pathologic and hematologic parameters were reviewed in a total of 154 patients with EOC submitted to primary cytoreductive surgery. Patients were categorized into two different groups accordin...

To overcome kidney donation, the pool of potentially eligible donors has been widened by using suboptimal organs harvested from living donors or cadavers. These organs may engender health complications as age, risk factors, and pathologies of donors fail to meet the standard donor criteria. After examining a wide array of literature on suboptimal kidney transplants, we evidenced two major issue...

OBJECTIVE To evaluate the occurrence and nature of suboptimal intrapartum care in cases with metabolic acidosis in the newborn, and to estimate the degree to which this may be prevented. DESIGN Case-control study. Clinical audit. Setting Delivery units at two university hospitals in Sweden. POPULATION Out of 28 486 deliveries, 161 neonates > or =34 weeks of gestational age were born with me...

Bounded suboptimal search algorithms are usually faster than optimal ones, but they can still run out of memory on large problems. This paper makes three contributions. First, we show how solution length estimates, used by the current stateof-the-art linear-space bounded suboptimal search algorithm Iterative Deepening EES, can be used to improve unboundedspace suboptimal search. Second, we conv...