PURPOSE To evaluate the effect of subconjunctival injections of combretastatin A-4 phosphate (CA-4P) prodrug treatment on tumor vasculature and growth in an animal model of hereditary retinoblastoma. METHODS Twenty-four, 12-week-old simian virus-40 T-antigen-positive mice received six subconjunctival CA-4P injections at doses of 0.5, 1.0, 1.5, and 2.0 mg delivered at 72-hour intervals to the ...

A 43-year-old man presented with giant papillary conjunctivitis of the left eye 5 months after retinal detachment repair silicone oil that was complicated by massive postoperative subconjunctival leak. Examination demonstrated clear mobile cysts in Tenon’s capsule for 360 degrees (Fig A), punctate keratopathy, and a reaction on superior tarsal conjunctiva B). Surgical excision cystic lesions pe...

Subconjunctival mydricaine injections are used in routine practice in patients with uveitis to prevent the formation of permanent posterior synechiae. Mydricaine No 2 (Moorfields Eye Hospital formulation) contains a combination of 6 mg procaine hydrochloride, 1 mg atropine sulphate and 0.12 ml epinephrine solution (1 in 1000). As it is normally injected subconjunctivally, this may prove difficu...

Despite various developments in many fields of ophthalmology, the surgical therapy of open-angle glaucoma has remained mostly unchanged over the last 30 years. Ever since the introduction of intraoperative mitomycin and postoperative subconjunctival injections of 5-fluorouracil (5-FU), trabeculectomy has not markedly been altered. These facts stand in contrast to the need for a more efficient s...