Biomarkers are indicators of a pathological or physiological state, and they essential for facilitating the diagnosis subclinical condition, understanding origin progression disease, stratifying risk, assessing response to specific therapeutic approach [...]

Recently, the molecular mechanism of the membrane abnormality that leads to an increased susceptibility of affected erythrocytes to complement, resulting in intravascular hemolysis, has been clarified in paroxysmal nocturnal hemoglobinuria (PNH).’4 The next concerns are the mechanisms of thrombosis and bone marrow (BM) hypoplasia that are the major causes of death. Progress in research on the h...

licensed dairy farms in the central region of Fars province were randomly selected in order to participate in aseasonal prevalence study. A cross-sectional study was designed to determine prevalence at cow and quarterlevel based on clinical signs for clinical mastitis and indirect tests for subclinical mastitis. 6180 quarters from1545 dairy cows were tested by clinical examination and Californi...

Background: Hyperprolactinemia is the most common endocrine disorder in hypothalamic-pituitary axis and has been reported in variable levels in patients with overt primary hypothyroidism. We decided to determine the prevalence of hyperprolactinemia and clinical related symptoms in subclinical hypothyroidism patients. Methods: In this cross sectional study, prolactin levels of 481 subclinical hy...

The potent and now longstanding evidence of the association between placentation-related disorders and cardiovascular disease should be translated into clinical practice in order to introduce a preventive approach to future obstetric and cardiovascular diseases. The purpose of this review is to integrate cardiovascular risk/disease and obstetric complications, which are linked by endothelial dy...

OBJECTIVES Several studies showed the close relationship between Rheumatoid Arthritis (RA) and cerebro-cardiovascular events (CVEs) and subclinical atherosclerosis. In this study, we investigated the occurrence of CVEs and subclinical atherosclerosis during the course of RA and we evaluated the possible role of both traditional cardiovascular (CV) and disease related risk factors to predict the...

Kawasaki disease is an acute inflammatory disorder of medium-sized arteries that predominantly affects cardiac coronary arteries and children under the age of 5 years. Cardiac involvement usually happens later than 10 days after the onset of illness. Most of cardiac complications are coronary artery abnormalities (ectasia or aneurysms) and subclinical myocarditis. Clinical myocarditis (symptoma...

BACKGROUND The impact of subclinical hypothyroidism on the cardiovascular risk is still debated. We aimed to measure the relationship between subclinical hypothyroidism and the left atrial (LA) pressure. METHODS The LA pressures and thyroid function were measured in consecutive patients undergoing atrial fibrillation (AF) ablation, who did not have any known heart failure, structural heart di...