BACKGROUND In general, organic solvents are inhibiting many physiological enzymes and alter the behavioural functions, but the available scientific knowledge on laboratory solvent induced organ specific toxins are very limited. Hence, the present study was planned to determine the sub-chronic toxic effects of petroleum ether (boiling point 40-60°C), a laboratory solvent in Sprague-Dawley (SD) r...

Bridelia ferruginea is a woody shrub that grows in the Savannah or rain forests of Africa and has traditionally been used to treat diabetes, arthritis and boils. Despite all these uses, extensive toxicological evaluation has not been carried out. The aim of the present investigation was to evaluate the sub-chronic toxicological effects of the stem bark aqueous extract of Bridelia ferruginea in ...

We studied the acute toxicity of a raw effluent from a battery manufacturing plant (Pilcam) in Douala, Cameroon, to a freshwater fish (Oreochromis niloticus), and subsequently evaluated its sub-acute effects on water quality and the biota in freshwater microscosms. The acute toxicity test was based on 96 hrs static renewal bioassays that resulted in 96-h LC50 and LC90 values of 16 and 20.7% (v/...

Four variables mean brood size, day of first reproduction, longevity and per capita rate of increase ( r ) -were compared in four 70-d chronic toxicity tests in which Daphnia pulex were exposed to cadmium or copper in continuous and pulsed exposures. With these data we asked the question: Is the population-level variable ( r ) more sensitive than the three organism-level variables (mean brood s...

Background: Recently, applications of nanoparticles in many fields of medicine have been developed, due to their specific physical and chemical properties. Therefore assessment of their toxicity specially in the in vivo condition is necessary. Objectives: The aim of this study is to evaluation the effect of Fe3O4 nanoparticles coating by biocompatible compounds on their t...

BACKGROUND Ficus glumosa Del (Moraceae), a plant used in traditional medicine in Cameroon, Senegal, and East Africa for the treatment of edema, hemorrhoid, cardiovascular diseases especially hypertension. AIM The present study evaluated the potential toxicity of the aqueous extract of the leaves of F.glumosa in acute and sub-chronic administration in rodents. METHODS Acute toxicity was eval...

This study aimed at evaluating toxicological implications of aqueous P. ostreatus extract (POE) in male Wistar rats. POE was prepared 1:10 (pulverized : distilled water). In acute toxicity test, single oral dose 2 mL/kg administered and observed for 28 days. The sub-chronic conducted by daily administration graded doses (0.25, 0.50 0.75 b.w) the Clinical signs toxicity, hematological, serum bio...

Cellular uptake of antisense oligonucleotides (ASOs) is one the main determinants in vivo activity and potency. A significant advancement improving into cells has come through conjugation ASOs to triantenarry N-acetyl-galactosamine (GalNAc3), a ligand for asialoglycoprotein receptor on hepatocytes. The impact oligonucleotides, which are already taken up hepatocytes, 10-fold im...

This strongly alkaline chemical is widely used in industry as a feed stock for nitrogen-based chemicals such as fertilizers, plastics and explosives (ATSDR, 1990). Ammonia is also used as a refrigerant. The general public is exposed by off-gasing from cleaning solutions containing aqueous ammonia. Household ammonia solutions contain 5-10% ammonia in water while industrial strength can be up to ...