Antibody-mediated immunity to Shigella, the causative agent of bacillary dysentery, requires several episodes of infection to get primed and is short-lasting, suggesting that the B cell response is functionally impaired. We show that upon ex vivo infection of human colonic tissue, invasive S. flexneri interacts with and occasionally invades B lymphocytes. The induction of a type three secretion...

Mobile Ad-hoc Networks (MANETs) in contrast to other networks have more vulnerability because of having nature properties, such as dynamic topology and no infrastructure. Therefore, a considerable challenge for these networks, is a method expansion that can specify anomalies with high accuracy at network dynamic topology alternation. In this paper, two methods were proposed for dynamic anomaly ...

Shigella flexneri contact with enterocytes induces a burst of protein secretion via its type III secretion apparatus (TTSA) as an initial step in cellular invasion. We have previously reported that IpaD is positioned at the TTSA needle tip (M. Espina et al., Infect. Immuno. 74:4391-4400, 2006). From this position, IpaD senses small molecules in the environment to control the presentation of Ipa...

The use of mobile learning offers new affordances to teaching and learning. In this study, students from two fourth grade classes used iPads in dyads and groups to learn about angle. Using a design-based research methodology, which included observations, video, researcher journals, and artefact collection, a local instruction theory was developed on how students can learn about angle concepts t...

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Young children are devoting more and more time to playing on handheld touchscreen devices (e.g., iPads). Though thousands of touchscreen apps are claimed to be "educational," there is a lack of sufficient evidence examining the impact of touchscreens on children's learning outcomes. In the present study, the two questions we focused on were (a) whether using a touchscreen was helpful in teachin...

BACKGROUND Validation of digital whole slide images is crucial to ensure that diagnostic performance is at least equivalent to that of glass slides and light microscopy. The College of American Pathologists Pathology and Laboratory Quality Center recently developed recommendations for internal digital pathology system validation. Following these guidelines we sought to validate the performance ...