in the present study, quantitative relationships between molecular structure and anti-tubercular activity of some 5-methyl/trifluoromethoxy-1 h -indole-2,3-dione-3-thiosemicarbazone derivatives were discovered. the detailed application of an efficient linear method and principal component regression (pcr) for the evaluation of quantitative structure activity relationships of the studied compound...

Rotundifolone, a monoterpene isolated from the essential oil of the leaves of Mentha x villosa, is a constituent of several essential oils and known to have antinociceptive activity. Our recent study demonstrated that the analogues of rotundifolone showed also a significant antinociceptive effect. In the present report, to investigate the correlation between the structure and antinociceptive ac...

New 2-phenylpyridazinones, analogs o f 4-chloro-5-methylamino-2-phenylpyridazin-3(2H)ones, were assayed for their phytotoxic activity to interfere with plant pigment formation. Six derivatives with — SCF3, — OCF2CH FCF3, — O CH F2, — CN, or — Br in meta position o f the phenyl ring exhibited similar or better bleaching activity than the m -CF3 analog (norflurazon). The activity is predominantly...