The cellular cytoskeleton, adhesion receptors, extracellular matrix composition, and their spatial distribution are together fundamental in a cell's balanced mechanical sensing of its environment. We show that, in lung injury, extracellular matrix-integrin interactions are altered and this leads to signalling alteration and mechanical missensing. The missensing, secondary to matrix alteration a...

This paper proposes an analysis of English, French, and German auxiliaries in the context of parallel grammar development. We present an LFG implementation of the analysis which factors out language particular morphological wellformedness conditions from linguistically generalizable contributions of auxiliaries. Auxiliaries are treated as feature carrying elements, rather than as raising verbs....

Abst rac t . Function-described graphs (FDGs) have been introduced very recently as a representation of an ensemble of attributed relational graphs (ARGs) for structural pattern recogrfition [1, 2]. In this paper, the relationship between FDGs and Random Graphs [3] is analysed and the synthesis process of FDGs is studied, whereas the matching process between FDGs and ARGs is discussed elsewhere...

Androgenic hormones are important in normal embryonic development and maintenance of the structural integrity of the penis. This structural integrity is vital in the physiology of penile erection. Its alteration may therefore lead to functional impairment resulting in erectile dysfunction as seen in hypogonadic conditions. The link between hypogonadism and erectile dysfunction is partly anatomi...

Mutations resulting in constitutive production of maltase have been identified at each of the five MAL loci of Saccharomyces yeasts. Here we examine a dominant constitutive, glucose-repression-insensitive allele of the MAL4 locus (MAL4-C). Our results demonstrate that MAL4-C is an alteration in the MAL43 gene, which encodes the positive regulator of the MAL structural genes, and that its produc...

Targeting modules or signalings may open a new path to understanding the complex pharmacological mechanisms of reversing disease processes. However, determining how to quantify the structural alteration of these signalings or modules in pharmacological networks poses a great challenge towards realizing rational drug use in clinical medicine. Here, we explore a novel approach for dynamic compara...