نتایج جستجو برای: stripped myometrium

تعداد نتایج: 5026  

Journal: :The Journal of endocrinology 2002
N Duckworth K Marshall J K Clayton

The aim of this study was to compare the effect of two known spasmogens, oxytocin and the stable thromboxane receptor mimetic, U46619, on human myometrium treated with the prostaglandin E receptor (EP2) agonist, butaprost (selective for the EP2 receptor). Strips of myometrium from pregnant and non-pregnant donors were set up in a superfusion apparatus. Butaprost was administered as a bolus dose...

Journal: :American journal of physiology. Cell physiology 1998
R Ann Word Trudy L Cornwell

Increases in guanosine 3',5'-cyclic monophosphate (cGMP) induced by nitric oxide (NO), nitrovasodilators, and atrial peptides correlate with relaxation of vascular smooth muscle. Relaxation of myometrial smooth muscle by increases in cGMP, however, has required unusually high concentrations of the cyclic nucleotide. We tested the hypothesis that the sensitivity of myometrium to relaxation by cG...

Journal: :Molecular human reproduction 2005
Shirley Astle Steven Thornton Donna M Slater

Prostaglandin E2 (PGE2) plays a key role in the maintenance of human pregnancy and labour onset. PGE2 can elicit diverse actions within the uterus depending on the PGE2 receptors (EP1, EP2, EP3 and EP4) expressed. By signalling through different intracellular pathways the EP receptors may inhibit or promote smooth muscle contractility. Nine different EP3 receptor splice variants have been ident...

Journal: :Clinical science 2001
C C Gentry S O Okolo L F Fong J C Crow A B Maclean C W Perrett

Although uterine leiomyomas constitute the commonest benign tumour in women, the regulation of their growth is poorly understood. It is believed that angiogenesis, the process by which new capillaries develop from pre-existing blood vessels, may be involved. We therefore investigated the expression of vascular endothelial growth factor-A (VEGF-A), a primary regulator of angiogenesis, in leiomyo...

2005
P. G. Adaikan A. Adebiyi P. Ganesan Adaikan

Objective: This study was carried out to examine the effect of functional modification of Caactivated Cl currents on contractile activities of isolated gravid rat myometrium. Materials and Methods: Spontaneous rhythmic and oxytocin-induced contractile activities of gravid rat myometrium in the presence and absence of Cl (in the bathing medium) were studied in a tissue bath system. The effects o...

Journal: :Reproductive biology 2004
Anita Franczak Izabela Wocławek-Potocka Agnieszka Oponowicz Beata Kurowicka Genowefa Kotwica

The possibility of PGF(2)alpha production and presence of prostaglandin F synthase (PGFS; PGD(2) 11-ketoreductase) was studied in control and oxytocin (OT)-stimulated myometrial slices isolated from cyclic (Days 14-16) and early pregnant (Days 14-16) sows. Oxytocin (10(-7) M) stimulated (p<0.01) PGF(2)alpha production in both cycling and early pregnant myometrial slices. Prostaglandin F(2)alpha...

Journal: :Molecular human reproduction 2001
W L Di G C Lachelin H H McGarrigle N S Thomas D L Becker

Oestradiol increases the protein expression of connexin43 (Cx43) gap junctions in myometrium but the effect of oestriol on gap junction expression has not been described previously. Oestriol is the most abundant free oestrogen in pregnant women and there is a marked surge in oestriol concentrations before term and idiopathic preterm labour. In order to determine whether oestriol may have a phys...

Journal: :American journal of physiology. Cell physiology 2005
Byoung Ywong Kim Chi-Heum Cho Dae-Kyu Song Kyo-Cheol Mun Seong-Il Suh Sang-Pyo Kim Dong-Hoon Shin Byeong-Churl Jang Taeg Kyu Kwon Soon-Do Cha Insoo Bae Jae Hoon Bae

This study investigated the acute effects of a peroxisome proliferator-activated receptor (PPAR)-gamma ligand, ciglitizone, on cell proliferation and intracellular Ca2+ signaling in human normal myometrium and uterine leiomyoma. Changes in intracellular Ca2+ concentration ([Ca2+]i) were measured with fura-2 AM, and cellular viabilities were determined by viable cell count and 3-(4,5-dimethyl-2-...

Journal: :Molecular human reproduction 2014
Sarah J Holdsworth-Carson Marina Zaitseva Beverley J Vollenhoven Peter A W Rogers

Uterine fibroids are conventionally defined as clonally derived benign tumours from the proliferation of a single smooth muscle cell (SMC). We have previously identified fibroblast-like cells in fibroids, the presence of which raises the question as to whether all cells within the fibroid have the same clonal origin. The first aim of this study was to develop a fluorescence-activated cell sorti...

2017
Polina A. Vishnyakova Maria A. Volodina Nadezhda V. Tarasova Maria V. Marey Natalya E. Kan Zulfiya S. Khodzhaeva Mikhail Yu. Vysokikh Gennady T. Sukhikh

Preeclampsia is a pregnancy complication which causes significant maternal and fetal morbidity and mortality worldwide. Although intensive research has been performed in the last 40 years, the pathology of preeclampsia is still poorly understood. The present work is a comparative study of the myometrium of women with normal pregnancy, and those with late- and early-onset preeclampsia (n = 10 fo...

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