Group B Streptococcus (GBS) is the major cause of human neonatal infections. A single clone, designated CC17-GBS, accounts for more than 80% meningitis cases, most severe form infection. However, events allowing blood-borne GBS to penetrate brain remain largely elusive. In this study, we identified host transmembrane receptors ?5?1 and ?v?3 integrins as ligands Srr2, a CC17-GBS–specific adhesin...

OBJECTIVES To re-examine the prevalence of group B Streptococcus colonisation in our antenatal population, and identify demographic factors associated with carriage. DESIGN Prospective observational study. SETTING A tertiary obstetrics unit in Hong Kong. PARTICIPANTS A total of 1002 pregnant women were recruited at the booking clinic in a tertiary obstetrics unit in Hong Kong. High and lo...