نتایج جستجو برای: stratified cox model
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Background and Purpose: Gastric cancer is the third leading cause of mortality in Iran after cardiovascular diseases and accidents. The aim of the present study was to assess survival and it’s affecting factors in gastric cancer patients through using Cox and parametric models along with frailty. Materials and Methods: In this study, the medical records of gastric cancer patients treat...
Background: Two main issues that challenge model building are number of Events Per Variable and multicollinearity among exploratory variables. Our aim is to review statistical methods that tackle these issues with emphasize on penalized Lasso regression model. The present study aimed to explain problems of traditional regressions due to small sample size and m...
OBJECTIVE This study aimed to analyze the effect of HbA1c variability on the occurrence of diabetic retinopathy in type 1 diabetes patients. PATIENTS AND METHODS 35,891 patients with childhood, adolescent or adult onset of type 1 diabetes from a large multicentre survey, the German/Austrian prospective documentation system (DPV), were analysed. Cox proportional hazard models were used to exam...
OBJECTIVES A survival analysis of breast cancer patients in southern Iran according to age has yet to be conducted. This study aimed to quantify the factors contributing to a poor prognosis, using Cox and empirical Bayesian additive hazard (EBAH) models, among young (20-39 years), middle-aged (40-64 years), and elderly (≥ 65 years) women. METHODS Data from 1,574 breast cancer patients diagnos...
BACKGROUND Morbidity and mortality rates are high among patients with end-stage renal disease (ESRD), and recent evidence suggests that this may be linked to inflammation. Current research has also demonstrated the crucial involvement of interleukin-18 (IL-18) in inflammation. In agreement, the activity of IL-18 has been markedly up-regulated in ESRD patients. However, it has not been establish...
Background and Objectives: Neuropathy is a common complication of diabetes that can cause disability in diabetic patients. The aim of this study was to determine of effective factors in the Event Time of neuropathy in type 2 diabetic patients using the Cox proportional hazards model. Methods: This study included 371 patients with type II diabetes without neuropathy who were registered at Fer...
These notes are part of the first chapter of a series of lectures given by the author in the spring of 1970. The ultimate aim of these notes will be to prove the theorem that the set of topologically stable mappings form a dense subset of C∞(N,P ) for any finite dimensional manifolds N and P where N is compact. The first chapter is a study of Thom–Whitney theory of stratified sets and stratifie...
چکیده: تحقیقات نشان میدهند که نیکوتین در غلظت هایی معادل غلظت خونی افراد سیگاری(نیکوتین دوز µg/ml50 با توجه به افراد سیگاری که روزانه تعداد کمتر از 15 نخ سیگار مصرف میکنند و دوزµg/ml 200 با توجه به افراد سیگاری که روزانه تعداد بیشتر از 30 نخ سیگار مصرف میکنند) باعث افزایش بیان آنزیم cox-2 و pge2 در سرطان کولون می شود. در واقع نیکوتین با تحریک تولید عوامل فوق میتواند درایجاد و پیشرفت سرطان موثر...
COX-2 inhibitory activities of some 1,4-dihydropyridine and 5-oxo-1,4,5,6,7,8-hexahydroquinoline derivatives were modeled by quantitative structure–activity relationship (QSAR) using stepwise-multiple linear regression (SW-MLR) method. The built model was robust and predictive with correlation coefficient (R2) of 0.972 and 0.531 for training and test groups, respectively. The quality of the mod...
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