BACKGROUND The determination of the osmolality of aqueous samples using a freezing point osmometer is a well-established, routine laboratory method. In addition to their use in clinical and pharmaceutical laboratories, freezing point osmometers are also employed in food testing laboratories. One application is the determination of the osmolality of milk. Although cow's milk is a natural product...

BACKGROUND Physical activity is known to have health benefits across population groups. However, less is known about changes over time in socioeconomic differences in leisure-time physical activity and the reasons for the changes. We hypothesised that class differences in leisure-time physical activity would widen over time due to declining physical activity among the lower occupational classes...

Epigenetic disruption has been implicated in many diseases of aging, and age-associated DNA methylation changes at specific genomic loci in humans are strongly correlated with chronological age. The aim of this study was to explore the specificity of selected age-associated differentially methylated positions (aDMPs) identified in human epidemiological studies by quantifying DNA methylation acr...

We present radio maps of the head-tail radio galaxy, 3C 129 at 240 and 610 MHz using the Giant Metrewave Radio Telescope. We have studied in detail the morphology of the source and the distribution of spectral index over the object. We find large-scale spectral steepening along the jet away from the core. Using synchrotron spectral ageing theory, we infer the age (time since particle accelerati...

BACKGROUND Common mental disorders (CMD) are prevalent in working populations and have adverse consequences for employee well-being and work ability, even leading to early retirement. Several studies report associations between psychosocial working conditions and CMD. However, there is a lack of longitudinal research within a broad framework of psychosocial working conditions and improvement in...

Inhibitory control can be investigated with the countermanding task, which requires subjects to make a response to a go signal and cancel that response when a stop signal is presented occasionally. Adult humans performing the countermanding task typically exhibit impaired response time (RT), stop signal response time (SSRT) and response accuracy as they get older, but little change in post-erro...

The aging process affects all body tissues including the brain and different hormones are reduced with aging in mammals. This research was performed to study the effects of 17β-estradiol on astrocyte density in CA1 region of hippocampus during the aging process. Female Wistar rats were divided into the following five groups: immature rats, mature rats in metestrus phase, mature rats treated wit...

Dietary restriction (DR) is a valuable experimental tool for studying the aging process. Primary advancement of research in this area has relied on rodent models, but attention has recently turned toward Drosophila melanogaster. However, little is known about the baseline effects of DR on wild-type Drosophila and continued experimentation requires such information. The findings described here s...

Recent work suggests that sexual selection can influence the evolution of ageing and lifespan by shaping the optimal timing and relative costliness of reproductive effort in the sexes. We used inbred lines of the decorated cricket, Gryllodes sigillatus, to estimate the genetic (co)variance between age-dependent reproductive effort, lifespan, and ageing within and between the sexes. Sexual selec...

Aging is a highly polygenic trait (Kirkwood, T.B.L., Franceschi, C., 1992. Is aging as complex as it would appear? Annals of the New York Academy of Sciences 663, 412-417) who's underlying mechanisms are still unresolved. Animal models are an important help for understanding this process and a recent report drew attention to a putative gene which causes variability in the life span among genoty...