The cerebral cortex, the neostriatum (Str), and the external segment of the globus pallidus (GPe) form a cortico-Str-GPe disynaptic connection, which is one of the major connections in the basal ganglia circuitries and a target of dopamine modulation. The aim of this study was to examine the actions of D2-like dopamine receptors (D2LRs) in this connection using rat brain slice preparations. Ele...

In recent years, there has been a rising interest in researching and finding new antimicrobial agents from various sources to fight against microbial infectious pathogens. Therefore, a greater attention has been paid to synthesize new molecules. In this regarding a straightforward two-step protocol for the synthesis of 2,3-disubstituted-4-thiazolidinone (4a-f) and 2,3disubstituted-5-methyl-4-th...

Paternity testing is being increasingly requested with the aim of challenging presumptive fatherhood. The ability to establish the biological father is usually based on the genotyping of autosomal short tandem repeat (STR) in alleged father, mother and child, but the use of Y-chromosomal STR has gained interest in the last few years. In this work, we propose a new probabilistic approach that co...

OBJECTIVES To study the suitability, stability and diversity of short tandem repeat (STR) genomic markers to elicit strain variation in the Mycobacterium leprae isolates within leprosy patients from Andhra Pradesh and Tamil Nadu states in South India. MATERIALS AND METHODS Slit skin smear (SSS) samples were collected from lesions and various body sites of newly diagnosed leprosy patients. The...

Subgenera of the speciose ant-like stone beetle genus Stenichnus Thomson are revised. The genus is re-classified and only two subgenera are retained: Stenichnus s. str. and Scydmaenichnus Reitter. Two remaining subgenera, Austrostenichnus Franz and Scydmaenilla King, are elevated to the genus rank (the status of Scydmaenilla, originally described as a genus and later reduced to a subgenus of St...

OBJECTIVE STR/ORT mice provide a well-known model for murine idiopathic OA, with histological joint lesions resembling those of human OA. This model was used to investigate protective effects of the dipeptide aspartyl-phenylalanine-1-methyl ester (Asp-Phe-OMe or aspartame) via the oral route vs a regular diet. METHODS STR/ORT mice were housed individually and fed diets with or without Asp-Phe...

the sarcoglycanopathies (sgps) are a subgroup of autosomal recessive limb girdle muscular dystrophies (lgmds). they are caused by mutations in gamma, alpha, beta, and delta sarcoglycans (sgs) genes. alpha-sgps are the most frequent form of sgps. muscle biopsy studies in patients with sarcoglycanopathies have indicated that loss of one sg subunit leads to instability of whole sg complex.  autozy...

let $d$ be a finite and simple digraph with vertex set $v(d)$‎.‎a signed total roman $k$-dominating function (str$k$df) on‎‎$d$ is a function $f:v(d)rightarrow{-1‎, ‎1‎, ‎2}$ satisfying the conditions‎‎that (i) $sum_{xin n^{-}(v)}f(x)ge k$ for each‎‎$vin v(d)$‎, ‎where $n^{-}(v)$ consists of all vertices of $d$ from‎‎which arcs go into $v$‎, ‎and (ii) every vertex $u$ for which‎‎$f(u)=-1$ has a...

INTRODUCTION Highly active antiretroviral therapy (HAART) has allowed many HIV-infected patients to enjoy longer survival and a better quality of life. We performed an economic analysis to estimate the cost-effectiveness of HAART regimens in Italy for managing HIV-naïve infected patients with a viral load below 100,000 copies/mL. PATIENTS AND METHODS The population considered in the model con...

genotyping for five short tandem repeat (str) loci humvwa, humfes, humtpo, humth01 and d3s1359 was done in 220 unrelated individuals from the population of isfahan province of ir iran. the loci were genotyped using the polymerase chain reaction (pcr) followed by polyacrylamide gel electrophoresis (page) and silver staining. the data demonstrated that the str markers were all found informative i...