This remarkable and paradigm-breaking discovery showed that bacterium Helicobacter pylori causes inflammation of the stomach or gastritis as well as the ulceration of the duodenum or the first part of the small intestines that is connected to the stomach. This discovery led to a radical change in the treatment of Peptic Ulcer Disease which now includes eradication of the bacteria and not just g...

RATIONALE Peutz-Jeghers syndrome (PJS) is an autosomal dominant genetic syndrome characterized by a unique type of gastrointestinal hamartomatous polyp associated with oral and anal mucocutaneous pigmentations. Peutz-Jeghers polyps occur most numerously in the small intestine but frequently in the colon and stomach, only a few cases have been reported in the duodenum. PATIENT CONCERN A furthe...

The effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on the gastric and duodenal mucosa was studied in 53 patients. On endoscopic biopsies, 87% patients showed gastritis and 90% duodenitis. Chronic superficial gastritis was the most frequent lesion in the stomach (49%); and mild duodenitis in the duodenum (54%). The antrum was the most frequently involved site in the stomach. An interest...