Data from two experimental studies with eight specimens each of spinal motion segments and/or intervertebral discs are presented in a form that can be used for comparison with finite element model predictions. The data include the effect of compressive preload (0, 250 and 500N) with quasistatic cyclic loading (0.0115Hz) and the effect of loading frequency (1, 0.1, 0.01 and 0.001Hz) with a physi...

although carbon nanotubes (cnt) have been employed as reinforcements in nanocomposites, presence of nano scale defects such as stone-wales and vacancy defects in carbon nanotubes (cnt) weakens the mechanical properties of these materials. in this paper the effects of defects in cnts on nanocomposite elastic behavior are investigated using molecular dynamics. stiffness matrices of cnt and nanoco...

Starting from the solutions of governing differential equations motion in free vibration, frequency dependent mass and stiffness matrices bar beam elements have been derived this paper, but importantly, their equivalency with corresponding dynamic matrix is established. In sharp contrast to series solutions, reported literature, explicit expressions for each term are generated concise form thro...

a frequency-wavenumber-domain formulation is presented in this paper for calculation of the green's functions and wave propagation modes in a stratified fluid body underlain by a layered viscoelastic soil medium. the green's functions define the solid and fluid displacements and fluid pressures due to uniform disk loads acting in either the soil or fluid media. the solution is in the frequency ...

The stiffness sensing ability is required to respond to the stiffness of the matrix. Here we determined whether normal cells and cancer cells display distinct mechanical phenotypes. Cancer cells were softer than their normal counterparts, regardless of the type of cancer (breast, bladder, cervix, pancreas, or Ha-RasV12-transformed cells). When cultured on matrices of varying stiffness, low stif...

A design process comprising aspects of modelling and analysis is developed, implemented and verified for a flexible rotor active magnetic bearing system. The system is specified to experience the first three critical frequencies up to an operating speed of 10,000 rpm. Rotor stability at critical frequencies places specific constraints on the equivalent stiffness and damping parameters of the ac...

The myofibroblastic differentiation of hepatic stellate cells (HSC) is a critical event in liver fibrosis and is part of the final common pathway to cirrhosis in chronic liver disease from all causes. The molecular mechanisms driving HSC differentiation are not fully understood. Because macroscopic tissue stiffening is a feature of fibrotic disease, we hypothesized that mechanical properties of...

Reductionist in vitro model systems which mimic specific extracellular matrix functions in a highly controlled manner, termed artificial extracellular matrices (aECM), have increasingly been used to elucidate the role of cell-ECM interactions in regulating cell fate. To better understand the interplay of biophysical and biochemical effectors in controlling three-dimensional cell migration, a po...

A new method is presented for identifying the local stiffness of a structure from vibration test data. The method is based on a projection of the experimentally measured flexibility matrix onto the strain energy distribution in local elements or regional superelements. Using both a presumed connectivity and a presumed strain energy distribution pattern, the method forms a well-determined linear...