Cancer is one of the major causes death in developed countries and current therapies are based on surgery, chemotherapeutic agents, radiation. To overcome side effects induced by chemo- radiotherapy, recent decades, targeted have been proposed second even first lines. Targeted drugs act essential pathways involved tumor induction, progression, metastasis, basically all hallmark cancers. Among e...

The purpose of this study was to evaluate the time-course effect of a 36-h treatment with ACTH (10 M), transforming growth factor-b1 (TGFb1; 10 M), angiotensin II (AngII; 10 M), and insulin-like growth factor I (IGF-I; 10 M) on the steroidogenic capacity of bovine adrenocortical cells (BAC) and on messenger RNA (mRNA) levels of ACTH receptor, cytochrome P450c17, 3b-hydroxysteroid dehydrogenase ...

Brominated flame retardants (BFRs) and brominated dioxins are emerging persistent organic pollutants that are ubiquitous in the environment and can be accumulated by wildlife and humans. These chemicals can disturb endocrine function. Recent studies have demonstrated that one of the mechanisms of endocrine disruption by chemicals is modulation of steroidogenic gene expression or enzyme activiti...

BACKGROUND Main function of corpus luteum is progesterone synthesis that is significantly accompanied with an increase in levels of mRNA encoding of steroidogenic enzymes known as luteal markers. OBJECTIVE This study was designed to evaluate effects of lithium chloride on the release of steroid hormones and steroidogenic enzymes in gonadotropin-stimulated rats. MATERIALS AND METHODS Immatur...

The nuclear receptor steroidogenic factor 1 (SF-1) is essential for adrenal development and steroidogenesis. The atypical orphan nuclear receptor Dax-1 binds to SF-1 and represses SF-1 target genes. Paradoxically, however, loss-of-function mutations of Dax-1 also cause adrenal hypoplasia, suggesting that Dax-1 may function as an SF-1 coactivator under some circumstances. Indeed, we found that D...