نتایج جستجو برای: stereoelectronic effect

تعداد نتایج: 1641819  

Journal: :Biochemistry 2006
Feng Li Sanjay Sarkhel Christopher J Wilds Zdzislaw Wawrzak Thazha P Prakash Muthiah Manoharan Martin Egli

2'-Deoxy-2'-fluoro-arabinonucleic acid (FANA) and arabinonucleic acid (ANA) paired to RNA are substrates of RNase H. The conformation of the natural DNA/RNA hybrid substrates appears to be neither A-form nor B-form. Consistent with this, the conformations of FANA and ANA were found to be intermediate between the A- and B-forms. However, FANA opposite RNA is preferred by RNase H over ANA, and th...

2014
Rohan J Williams Javier Iglesias-Fernández Judith Stepper Adam Jackson Andrew J Thompson Elisabeth C Lowe Jonathan M White Harry J Gilbert Carme Rovira Gideon J Davies Spencer J Williams

Mannosidases catalyze the hydrolysis of a diverse range of polysaccharides and glycoconjugates, and the various sequence-based mannosidase families have evolved ingenious strategies to overcome the stereoelectronic challenges of mannoside chemistry. Using a combination of computational chemistry, inhibitor design and synthesis, and X-ray crystallography of inhibitor/enzyme complexes, it is demo...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه فردوسی مشهد - دانشکده ادبیات و علوم انسانی دکتر علی شریعتی 1392

هدف این مطالعه تعیین کردن این مساله است که آیا فراگیران فارسی زبان قادر به تطبیق پارامتری ضمیر موصولی that در جملات ساده و پیچیده ی انگلیسی در سایه اصل دستور جهانی هستند یا خیر. به علاوه نقش جنسیت در رابطه با آزمون تشخیص درستی یا نادرستی جملات دستوری مورد بررسی قرار گرفت. داده ها از 54 دانشجوی فراگیر زبان انگلیسی در دانشگاه فردوسی مشهد گردآوری شد. شرکت کنندگان در آزمون شامل 28 زن (51.85 درصد)و ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه یزد 1388

there is less published research about how teachers in efl contexts respond to students who are relatively less mature and less competent l2 writers. while writing researchers have examined various issues concerning peer and teacher response in writing-oriented classes, little research has centered on the effect of collaborative tasks particularly dictogloss on writing skills. output collaborat...

Journal: :Zeitschrift fur Naturforschung. C, Journal of biosciences 2001
M Miyashita T Nakamori T Murai T Yonemoto H Miyagawa M Akamatsu T Ueno

AM-toxins are host-specific phytotoxins of the Alternaria alternata apple pathotype, which induce necrosis on apple leaves. In this study, we developed a new assay to measure the necrotic activity of AM-toxin analogs using cultured leaves from meristem cells. This method was not only more sensitive to AM-toxin I, but also more reliable than the previous one that used tree leaves due to the homo...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2010
Matthew D Shoulders Kenneth A Satyshur Katrina T Forest Ronald T Raines

Preorganization is shown to endow a protein with extraordinary conformational stability. This preorganization is achieved by installing side-chain substituents that impose stereoelectronic and steric effects that restrict main-chain torsion angles. Replacing proline residues in (ProProGly)(7) collagen strands with 4-fluoroproline and 4-methylproline leads to the most stable known triple helices...

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