Setting and participants. 664 patients aged ≥ 18 years who presented to their primary care provider in the Netherlands for new-onset dyspepsia between 2003 and 2006. Patients were assigned to either step-up or step-down therapy. Step-up therapy started with antacids, switched to H2-receptor antagonists, and then ended with proton pump inhibitors (PPIs). Step-down therapy employed the same medic...

Controlling the false discovery rate has been increasingly utilized in high dimensional screening studies where multiplicity is a problem. Most methods do not explicitly take the correlation between the data or the test statistics into account, with consequent loss of power. In this paper, we use least favorable configurations to obtain critical values for both step-down and step-up procedures,...

In order to provide a scientific basis for rational use of antibiotics, we studied and compared the therapeutic effects of step-down and step-up antibiotic treatment schemes in children with lobar pneumonia. Eighty cases of children with lobar pneumonia were enrolled in this study and were randomly divided into two groups: The observation group and the control group, with 40 cases in each group...

In multiple hypotheses testing, it is important to control the probability of rejecting “true” null hypotheses. A standard procedure has been to control the family-wise error rate (FWER), the probability of rejecting at least one true null hypothesis. For large numbers of hypotheses, using FWER can result in very low power for testing single hypotheses. Recently, powerful multiple step FDR proc...

Holm’s method and Hochberg’s method for multiple testing can be viewed as step-down and step-up versions of the Bonferroni test. We show that both are special cases of partition testing. The difference is that, while Holm’s method tests each partition hypothesis using the largest order statistic, setting a critical value based on the Bonferroni inequality, Hochberg’s method tests each partition...

We further study the incidence relations that arise from the various subtowers, known as Baby Monsters, which exist within the R-Monster Tower. This allows us to complete the RV T class spelling rules. We also present a method of calculating the various Baby Monsters that appear within the Monster Tower. MSC Primary: 58A30 Secondary: 58A17, 58K50.

SN 2002kg is a type IIn supernova, detected in October 2002 in the nearby spiral galaxy NGC 2403. We show that the position of SN 2002kg agrees within the errors with the position of the LBV V37. Ground based and HST ACS images however show that V37 is still present after the SN 2002kg event. We compiled a lightcurve of V37 which underlines the variablity of the object, and shows that SN 2002kg...