نتایج جستجو برای: statistical deficiencies

تعداد نتایج: 392628  

2014
Holly L. Baines James B. Stewart Craig Stamp Anze Zupanic Thomas B.L. Kirkwood Nils-Göran Larsson Douglass M. Turnbull Laura C. Greaves

Clonally expanded mitochondrial DNA (mtDNA) mutations resulting in focal respiratory chain deficiency in individual cells are proposed to contribute to the ageing of human tissues that depend on adult stem cells for self-renewal; however, the consequences of these mutations remain unclear. A good animal model is required to investigate this further; but it is unknown whether mechanisms for clon...

Journal: :Experimental gerontology 2009
Alexandra Kukat Aleksandra Trifunovic

Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in various human tissues, such as heart, skeletal muscle, colonic crypts and neurons. S...

Journal: :Folia Oeconomica Stetinensia 2011

Journal: :Bulletin of the Australian Mathematical Society 1990

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