نتایج جستجو برای: stat 6

تعداد نتایج: 965805  

2017
Graham Akeson Charles J. Malemud

Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines present at elevated levels in the synovial fluid of individuals with confirmed clinical diagnosis of rheumatoid arthritis (RA) and osteoarthritis (OA). The mechanism of action of IL-6 was shown to involve its capacity to interact with a membrane-bound IL-6 receptor (mIL-6Rα), also known as the "classical" IL-6 pathway, or through...

Journal: :Genome Biology 2001

2016
Jie-Jie Sun Hui-Ting Yang Guo-Juan Niu Xiao-Wu Feng Jiang-Feng Lan Xiao-Fan Zhao Jin-Xing Wang

Impaired phosphatase activity leads to the persistent activation of signal transducers and activators of transcription (Stat). In mammals, Stat family members are often phosphorylated or dephosphorylated by the same enzymes. To date, only one Stat similar to mammalian Stat5a/b has been found in crustaceans and there have been few studies in Stat signal regulation in crustaceans. Here, we report...

Journal: :JAK-STAT 2012

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2011
Cécile Taflin Benoit Favier Jeremy Baudhuin Alain Savenay Patrice Hemon Armand Bensussan Dominique Charron Denis Glotz Nuala Mooney

Organ transplantation represents a unique therapeutic option for irreparable organ dysfunction and rejection of transplants results from a breakdown in operational tolerance. Although endothelial cells (ECs) are the first target in graft rejection following kidney transplantation, their capacity to alloactivate and generate particular T lymphocyte subsets that could intervene in this process re...

Journal: :Physical review letters 2004
B Aubert R Barate D Boutigny J-M Gaillard A Hicheur Y Karyotakis J P Lees P Robbe V Tisserand A Zghiche A Palano A Pompili J C Chen N D Qi G Rong P Wang Y S Zhu G Eigen I Ofte B Stugu G S Abrams A W Borgland A B Breon D N Brown J Button-Shafer R N Cahn E Charles C T Day M S Gill A V Gritsan Y Groysman R G Jacobsen R W Kadel J Kadyk L T Kerth Yu G Kolomensky J F Kral G Kukartsev C LeClerc M E Levi G Lynch L M Mir P J Oddone T J Orimoto M Pripstein N A Roe A Romosan M T Ronan V G Shelkov A V Telnov W A Wenzel K Ford T J Harrison C M Hawkes D J Knowles S E Morgan R C Penny A T Watson N K Watson T Deppermann K Goetzen H Koch B Lewandowski M Pelizaeus K Peters H Schmuecker M Steinke N R Barlow J T Boyd N Chevalier W N Cottingham M P Kelly T E Latham C Mackay F F Wilson K Abe T Cuhadar-Donszelmann C Hearty T S Mattison J A McKenna D Thiessen P Kyberd A K McKemey V E Blinov A D Bukin V B Golubev V N Ivanchenko E A Kravchenko A P Onuchin S I Serednyakov Yu I Skovpen E P Solodov A N Yushkov D Best M Chao D Kirkby A J Lankford M Mandelkern S McMahon R K Mommsen W Roethel D P Stoker C Buchanan D del Re H K Hadavand E J Hill D B MacFarlane H P Paar Sh Rahatlou U Schwanke V Sharma J W Berryhill C Campagnari B Dahmes N Kuznetsova S L Levy O Long A Lu M A Mazur J D Richman W Verkerke T W Beck J Beringer A M Eisner C A Heusch W S Lockman T Schalk R E Schmitz B A Schumm A Seiden M Turri W Walkowiak D C Williams M G Wilson J Albert E Chen G P Dubois-Felsmann A Dvoretskii D G Hitlin I Narsky F C Porter A Ryd A Samuel S Yang S Jayatilleke G Mancinelli B T Meadows M D Sokoloff T Abe T Barillari F Blanc P Bloom S Chen P J Clark W T Ford U Nauenberg A Olivas P Rankin J Roy J G Smith W C van Hoek L Zhang J L Harton T Hu A Soffer W H Toki R J Wilson J Zhang D Altenburg T Brandt J Brose T Colberg M Dickopp R S Dubitzky A Hauke H M Lacker E Maly R Müller-Pfefferkorn R Nogowski S Otto K R Schubert R Schwierz B Spaan L Wilden D Bernard G R Bonneaud F Brochard J Cohen-Tanugi Ch Thiebaux G Vasileiadis M Verderi A Khan D Lavin F Muheim S Playfer J E Swain J Tinslay M Andreotti D Bettoni C Bozzi R Calabrese G Cibinetto E Luppi M Negrini L Piemontese A Sarti E Treadwell F Anulli R Baldini-Ferroli A Calcaterra R de Sangro D Falciai G Finocchiaro P Patteri I M Peruzzi M Piccolo A Zallo A Buzzo R Contri G Crosetti M Lo Vetere M Macri M R Monge S Passaggio F C Pastore C Patrignani E Robutti A Santroni S Tosi S Bailey M Morii M L Aspinwall W Bhimji D A Bowerman P D Dauncey U Egede I Eschrich G W Morton J A Nash P Sanders G P Taylor G J Grenier S-J Lee U Mallik J Cochran H B Crawley J Lamsa W T Meyer S Prell E I Rosenberg J Yi M Davier G Grosdidier A Höcker S Laplace F Le Diberder V Lepeltier A M Lutz T C Petersen S Plaszczynski M H Schune L Tantot G Wormser V Brigljević C H Cheng D J Lange D M Wright A J Bevan J P Coleman J R Fry E Gabathuler R Gamet M Kay R J Parry D J Payne R J Sloane C Touramanis J J Back P F Harrison H W Shorthouse P Strother P B Vidal C L Brown G Cowan R L Flack H U Flaecher S George M G Green A Kurup C E Marker T R McMahon S Ricciardi F Salvatore G Vaitsas M A Winter D Brown C L Davis J Allison R J Barlow A C Forti P A Hart F Jackson G D Lafferty A J Lyon J H Weatherall J C Williams A Farbin A Jawahery D Kovalskyi C K Lae V Lillard D A Roberts G Blaylock C Dallapiccola K T Flood S S Hertzbach R Kofler V B Koptchev T B Moore S Saremi H Staengle S Willocq R Cowan G Sciolla F Taylor R K Yamamoto D J J Mangeol M Milek P M Patel A Lazzaro F Palombo J M Bauer L Cremaldi V Eschenburg R Godang R Kroeger J Reidy D A Sanders D J Summers H W Zhao C Hast P Taras H Nicholson C Cartaro N Cavallo G De Nardo F Fabozzi C Gatto L Lista P Paolucci D Piccolo C Sciacca M A Baak G Raven J M LoSecco T A Gabriel B Brau T Pulliam J Brau R Frey C T Potter N B Sinev D Strom E Torrence F Colecchia A Dorigo F Galeazzi M Margoni M Morandin M Posocco M Rotondo F Simonetto R Stroili G Tiozzo C Voci M Benayoun H Briand J Chauveau P David Ch de la Vaissière L Del Buono O Hamon M J J John Ph Leruste J Ocariz M Pivk L Roos J Stark S T'Jampens P F Manfredi V Re L Gladney Q H Guo J Panetta C Angelini G Batignani S Bettarini M Bondioli F Bucci G Calderini M Carpinelli F Forti M A Giorgi A Lusiani G Marchiori F Martinez-Vidal M Morganti N Neri E Paoloni M Rama G Rizzo F Sandrelli J Walsh M Haire D Judd K Paick D E Wagoner N Danielson P Elmer C Lu V Miftakov J Olsen A J S Smith E W Varnes F Bellini G Cavoto R Faccini F Ferrarotto F Ferroni M Gaspero M A Mazzoni S Morganti M Pierini G Piredda F Safai Tehrani C Voena S Christ G Wagner R Waldi T Adye N De Groot B Franek N I Geddes G P Gopal E O Olaiya S M Xella R Aleksan S Emery A Gaidot S F Ganzhur P-F Giraud G Hamel de Monchenault W Kozanecki M Langer G W London B Mayer G Schott G Vasseur Ch Yeche M Zito M V Purohit A W Weidemann F X Yumiceva D Aston R Bartoldus N Berger A M Boyarski O L Buchmueller M R Convery D P Coupal D Dong J Dorfan D Dujmic W Dunwoodie R C Field T Glanzman S J Gowdy E Grauges-Pous T Hadig V Halyo T Hryn'ova W R Innes C P Jessop M H Kelsey P Kim M L Kocian U Langenegger D W G S Leith S Luitz V Luth H L Lynch H Marsiske S Menke R Messner D R Muller C P O'Grady V E Ozcan A Perazzo M Perl S Petrak

We report a measurement of the inclusive charmless semileptonic branching fraction of B mesons in a sample of 89 x 10(6) (-)BB events recorded with the BABAR detector at the Upsilon(4S) resonance. Events are selected by fully reconstructing the decay of one B meson and identifying a charged lepton from the decay of the other B meson. The number of signal events is extracted from the mass distri...

Journal: :Molecular cancer therapeutics 2004
Takayuki Ikezoe Tsuyako Saito Kentaro Bandobashi Yang Yang H Phillip Koeffler Hirokuni Taguchi

We previously showed that HIV-1 protease inhibitors slowed the proliferation of human myeloid leukemia cells and enhanced their differentiation in the presence of all-trans retinoic acid (ATRA). In this study, we found that protease inhibitors, including ritonavir, saquinavir, and nelfinavir, but not indinavir, induced growth arrest and apoptosis of U266, RPMI8226, and ARH77 human multiple myel...

Journal: :Infection and immunity 2005
Chien-Chang Chen Steve Louie Beth McCormick W Allan Walker Hai Ning Shi

Infections with intestinal helminth and bacterial pathogens, such as enteropathogenic Escherichia coli, continue to be a major global health threat for children. To test the hypothesis that intestinal helminth infection may be a risk factor for enteric bacterial infection, a murine model was established by using the intestinal helminth Heligomosomoides polygyrus. To analyze the modulatory effec...

Journal: :Cytokine & Growth Factor Reviews 2007

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