نتایج جستجو برای: starting treatment dose
تعداد نتایج: 1692094 فیلتر نتایج به سال:
BACKGROUND Biologically based dose-response (BBDR) models can incorporate data on biological processes at the cellular and molecular level to link external exposure to an adverse effect. OBJECTIVES Our goal was to examine the utility of BBDR models in estimating low-dose risk. METHODS We reviewed the utility of BBDR models in risk assessment. RESULTS BBDR models have been used profitably ...
PURPOSE To optimize dose distribution for prostate cancer in low-dose-rate interstitial brachytherapy, we have developed a new algorithm named the Attraction-Repulsion Model. The purpose was to find the optimal source configuration. METHODS AND MATERIALS The Attraction-Repulsion Model is used to optimize the dose distribution by finding the best seed configuration. We arranged grids at interv...
The CERERRA database provides evidence that low-dose rituximab performs as well as the conventional dose in the real world, thus highlighting the possible pharmacoeconomic impact. In clinical trials, it has been shown that rituximab 500 mg twice, performs as well as 1 g twice, 2 weeks apart, in terms of the American College of Rheumatology (ACR)20 and ACR50, but not the ACR70. The choice should...
In mice, five injections of sub-diabetogenic doses of streptozotocin (STZ) may cause diabetes mellitus associated with lymphocyte infiltration of pancreatic islets1*^. There is evidence implicating autoimmune processes in the pathogenesis of this experimental diabetes3 > 4). Significantly, the development of this diabetes was prevented by rabbit anti-mouse lymphocyte serum5). Since deoxyspergua...
In order to evaluate the effect of olive juice on the anxiety and depression behavior, the paper uses olive juice concentrate as experimental material, and uses mice as experimental subjects. Mice are randomly divided into negative, positive, high, medium and low-dose group, administered orally for 7 days. And observe the impact on the mice elevated plus maze test, the opening acts test and for...
BACKGROUND Oral isotretinoin has been used to treat mild to severe hidradenitis suppurativa (HS). OBJECTIVE We reviewed the results of low-dose isotretinoin for 4 to 6 months in the treatment of 68 patients with HS. METHODS This is a retrospective study. Data are presented in terms of response rate, long-term follow-up, and the relation between response rate and severity. RESULTS In 16 pa...
OBJECTIVE To characterize the reversibility of natalizumab-mediated changes in pharmacokinetics/pharmacodynamics in patients with multiple sclerosis (MS) following therapy interruption. METHODS Pharmacokinetic/pharmacodynamic data were collected in the Safety and Efficacy of Natalizumab in the Treatment of Multiple Sclerosis (AFFIRM) (every 12 weeks for 116 weeks) and Randomized Treatment Int...
Asymptomatic elevation of the international normalized ratio (INR) is a common problem associated with hemorrhage. Evidence from randomized controlled trials supports the use of low-dose oral vitamin K therapy as a treatment that promptly reduces the INR. Vitamin K given orally is more effective than subcutaneous vitamin K injection, and as effective as intravenous administration when INR value...
High doses of ionizing radiation clearly produce deleterious consequences in humans, including, but not exclusively, cancer induction. At very low radiation doses the situation is much less clear, but the risks of low-dose radiation are of societal importance in relation to issues as varied as screening tests for cancer, the future of nuclear power, occupational radiation exposure, frequent-fly...
Intravenous enzyme replacement therapy (Alglucerase; Ceredase; Genzyme Corp, Boston, MA) is an effective and safe treatment for patients with type 1 Gaucher disease. In an attempt to reduce its high cost, a "low-dose high-frequency" protocol (30 U/kg/mo, 3 times a week) was introduced and found to be as effective as the original high-dose protocol (60 U/kg every 2 weeks). Because receiving freq...
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