objective: several studies have shown the improving effect of heparin on the outcomes of art. moreover, it has been reported that adding heparin in non-thrombophilia patients with rif is useful.the aim of this study was to evaluate the beneficial effects of heparin on art outcomes in women with history of recurrent implantation failure (rif) and without history of congenital or acquired thrombo...

background: low molecular weight heparin (lmwh) is used for the treatment and prevention of coagulative disorders. few patients receiving therapeutic doses of lmwh develop major hemorrhage. currently there are few reports in the literature on acute overdose on adults.  in this study, clinical profile, treatment and outcome of 21 patients who acutely overdosed enoxaparin are described. methods: ...

HYPOTHESIS Children who undergo cardiopulmonary bypass (CPB) are proportionally more hemodiluted than adults who undergo CPB. Current methods of monitoring high-dose heparin sulfate anticoagulation are dependent on fibrinogen level. Because of the decreased fibrinogen levels in children, current methods of monitoring heparin anticoagulation overestimate their level of anticoagulation. DESIGN ...

Background: Prevention of catheter-related infection is of prime importance,. However, because of the risks caused by the leakage of circulating antibiotics and development of resistance to antibiotics, they are replaced by lock solutions. The aim of this study was to evaluate the efficacy and cost- effectiveness of taurolidine-citrate as a hemodialysis catheter lock solution compared to other ...

The bone morphogenetic protein 6 (BMP6) is a crucial inducer of hepcidin, the peptide hormone that regulates iron availability in our body. Hepcidin expression influenced by hepatic heparan sulfate (HS) and heparin administration, suggesting BMP6 interaction with heparin/HS. BMP2/4 subfamily has been deeply characterized to have N-terminal heparin/HS binding domain (HBD), whose basic residues c...

Heparin-induced thrombocytopenia (HIT) is associated with high morbidity and mortality. Because the pathophysiology of this complex disorder has remained unclear, so has the development of supportive diagnostic laboratory assays. The currently available laboratory methods for HIT diagnosis include several platelet function assays: the platelet aggregation assay, platelet aggregation with simult...

We studied the mode of action of the low molecular weight heparin PK10169 and two of its constituent fractions: EMT 966 High Molecular Weight Fraction and EMT 967 Low Molecular Weight Fraction. EMT 966 like standard heparin, acts primarily on thrombin formed and not on prothrombinase (S type heparin). In contrast EMT 967 has no direct effect on thrombin. At high concentrations, it inhibits the ...

Anticoagulant use, such as heparin, is usually contraindicated in acute stroke patients. We present a study of patients, who were treated with intravenous heparin after a stroke that were also found to have an intraluminal thrombus. Prior studies imply that recanalization is achieved with heparin; however heparin should only prevent thrombus propagation. Therefore it is unclear whether and how ...

BACKGROUND The potential risk of vascular complications associated with heparin, the dose of heparin therapy has not been exactly examined in patients undergoing transradial angiography. Thus, this study was aimed to compare referral arterial thrombosis, hematoma and hemorrhagic complications with 2500 and 5000 IU arterial heparin and the association of these complications with predictors in pa...