Certain members of the morbillivirus genus, canine distemper virus, phocine distemper virus, and the cetacean viruses of dolphins and porpoises exhibit high levels of central nervous system (CNS) infection in their natural hosts. CNS complications are rare for measles virus (MV) and are not associated with rinderpest virus (RPV) and peste des petits ruminants virus (PPRV) infection. However, bo...

Acute measles (for review see: Grif®n and Bellini, 1996) can be accompanied by early or late central nervous system (CNS) complications. These include the acute postinfectious measles encephalitis (APME), which develops 2 ± 4 weeks after infection, or as late complications, the measles inclusion body encephalitis (MIBE) in immunocompromised patients, and the subacute sclerosing panencephalitis ...

In patients with subacute sclerosing panencephalitis (SSPE), which is associated with persistent measles virus (MV) infection in the brain, little infectious virus can be recovered despite the presence of viral RNA and protein. Based on studies of brain tissue from SSPE patients and our work with MV-infected NSE-CD46(+) mice, which express the measles receptor CD46 on neurons, several lines of ...

Introduction Subacute sclerosing panencephalitis (SSPE) is a rare disease which predominantly affects children of school age. The clinical features include an insidious afebrile onset with behavioural disturbance and progressive dementia sometimes associated with epilepsy. Later akinetic mutism and myoclonic jerks with pyramidal and extrapyramidal signs appear. Finally there is progressive deco...

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during a period of 7 years (1997-2003) we were received pairs of serum and csf of 27 suspicious clinically cases from neurology department of several hospitals in tehran. among them 7 were serologically positive for progressive rubella panencephalitis (prpe) and 2 were positive for sub acute sclerosing panencephalitis (sspe). rubella virus was isolated from 4 of 7 serologically positive cases o...