most common sexually transmitted infections (STIs), is the primary cause of cervical cancer. HPV infection is a necessary but not sufficient precursor to cervical cancer. While the cumulative lifetime incidence of acquiring HPV is 70 to 80 percent in many countries, the vast majority of women with HPV infection will not develop cancer (see PATH’s fact sheet, Natural History of Cervical Cancer)....

Testing for DNA of 13 high-risk HPV types with the Hybrid Capture 2 (HC2) test has consistently been shown to perform better in triage of women with cervical cytology results showing atypical squamous cells of undetermined significance (ASC-US) but often not in triage of low-grade squamous intraepithelial lesions (LSIL) detected in cervical cancer screening. In a meta-analysis, we compared the ...

This study develops a spectroscopic algorithm for detection of cervical high grade squamous intraepithelial lesions (HSILs). We collected reflectance and fluorescence spectra with the quantitative spectroscopy probe to measure nine spectroscopic parameters from 43 patients undergoing standard colposcopy with directed biopsy. We found that there is improved accuracy for distinguishing HSIL from ...

Prediction of the clinical outcome of nonadvanced, early dysplastic lesions is one of the unresolved problems of cervical cancer screening programs. We examined the influence of human papillomavirus (HPV) L1 capsid protein detection in a randomized, prospective study of 187 high-risk HPV+ early dysplastic lesions during 36 to 46 months. The difference in the clinical outcome of the HPV L1- case...

OBJECTIVE Evaluate the relationships between AgNORs polymorphisms and squamous intraepithelial lesions (SIL) and squamous cell carcinoma (SCC) with HPV infection. MATERIALS AND METHODS A study was carried out on sixty women from the state of Guerrero, Mexico. HPV detection was performed by PCR. AgNORs were identified by argentic impregnation. One hundred cells per slide were counted and class...

AIM To investigate the oncologically safe limits of excision in large loop excision of the transformation zone (LLETZ) conisation performed for cervical pathology. PATIENTS AND METHODS A retrospective study conducted at the Colposcopy Unit in a University Hospital setting. Three hundred and sixty-one cases of LLETZ conisation were conducted in a 2-year period. Data concerning age, cone dimens...

although the diagnostic category of atypical squamous cells of undetermined significance (ascus) has been known since 1988, its use and appropriate clinical follow up and management still remains controversial. this study was carried out to evaluate the diagnostic value of ascus, using cytohistologic correlation. a retrospective review of archival materials in our cytology laboratory files was ...

OBJECTIVE Evaluating the opportunity and access to diagnosis and treatment for females having had an abnormal Pap smear (high-grade epithelial lesion and cervical cancer) in Colombia from June 2005 to June 2006. MATERIALS AND METHODS This was a retrospective appraisal using a semi-closed survey of females having had an abnormal Pap smear with high squamous intraepithelial lesions or cervical ...

OBJECTIVE To strengthen the role of high-risk human papillomaviruses (HPVs) in the development of cervical cancer, and the association between HPV and the cell cycle inhibitor gene p16ink4a in cervical carcinogenesis. METHODS In this study, the association between p16ink4a and the presence of HPV DNA in cervical lesions was investigated in a total of 177 cervical biopsies classified as benign...

A 23-year-old woman gave a history of intermittent post-coital vaginal spotting, and a Papanicolaou smear indicated the presence of a low-grade squamous intraepithelial lesion and cellular changes due to the cytopathic effect of human papillomavirus (HPV) infection. Colposcopic examination showed a circumferential exophytic lesion (Fig 1). Multiple biopsies were performed; histological examinat...