Sleeping patterns have been one of the most essential aspects one’s lives, which also contribute to memorization and learning. However, undergraduate students seem underestimate importance sleep by skipping a night spend time on other works. As result, their academic performance is affected due poor quality. Thus, this study was conducted examine relationship between quality among in Sabah. Thi...

In this paper we describe the preparation of some biphenylquinuclidine derivatives and their evaluation as inhibitors of squalene synthase in order to explore their potential in the treatment of the parasitic diseases leishmaniasis and Chagas disease. The compounds were screened against recombinant Leishmania major squalene synthase and against Leishmania mexicana promastigotes, Leishmania dono...

Configuration (x-)space renormalization of euclidean Feynman amplitudes in a massless quantum field theory is reduced to the study of local extensions of associate homogeneous distributions. Primitively divergent graphs are renormalized, in particular, by subtracting the residue of an analytically regularized expression. Examples are given of computing residues that involve zeta values. The ren...

Staphylococcus aureus produces a golden carotenoid virulence factor called staphyloxanthin (STX), and we report here the inhibition of the enzyme, dehydrosqualene synthase (CrtM), responsible for the first committed step in STX biosynthesis. The most active compounds are halogen-substituted phosphonosulfonates, with K(i) values as low as 5 nM against the enzyme and IC(50) values for STX inhibit...

An investigation into the mechanism of antihyperlipidemic action of 2-chloromethyl-5,6,7,8-tetrahydrobenzo(b)thieno[2,3-d]pyrimidin-4(3H)-one (LM-1554) was carried out through docking experiments with six different molecular targets; Niemann Pick C1 Like1 protein (NPC1L1), ATP citrate lyase (ACL), C-reactive protein (CRP), lanosterol 14α-demethylase (LDM), squalene synthase (SqS) and farnesiod ...

Celastrol is an active triterpenoid compound derived from Tripterygium wilfordii which is well-known as a traditional Chinese medicinal plant. Squalene synthase has a vital role in condensing two molecules of farnesyl diphosphate to form squalene, a key precursor of triterpenoid biosynthesis. In the present study, T. wilfordii squalene synthase (TwSQS) was cloned followed by prokaryotic express...

Abstract Background and Aims Chronic kidney disease associated pruritus (CKD-aP) has been recognized for over a century. The actual proposed off-label therapeutic option is gabapentin, that showed relevant efficacy in some small trial. Recently difelikefalin (DFK), k-opioid receptor agonist, the first FDA EMA approved drug CKD-aP treatment. We report three treated patients suffering gabapentin-...