نتایج جستجو برای: splicing modulation
تعداد نتایج: 176802 فیلتر نتایج به سال:
Trimethylation of histone H3K36 is a chromatin mark associated with active gene expression, which has been implicated in coupling transcription with mRNA splicing and DNA damage response. SETD2 is a major H3K36 trimethyltransferase, which has been implicated as a tumor suppressor in mammals. Here, we report the regulation of SETD2 protein stability by the proteasome system, and the identificati...
To elucidate the structural determinants governing specificity in fibroblast growth factor (FGF) signaling, we have determined the crystal structures of FGF1 and FGF2 complexed with the ligand binding domains (immunoglobulin-like domains 2 [D2] and 3 [D3]) of FGF receptor 1 (FGFR1) and FGFR2, respectively. Highly conserved FGF-D2 and FGF-linker (between D2-D3) interfaces define a general bindin...
L-type calcium channels are composed of a pore, 1c (CaV1.2), and accessory and 2 subunits. The -subunit core structure was recently resolved at high resolution, providing important information on many functional aspects of channel modulation. In this study we reveal differential novel effects of five 2-subunits isoforms expressed in human heart ( 2a-e) on the single L-type calcium channel curre...
BACKGROUND Congenital adrenal hyperplasia (CAH) due to steroid 11β-hydroxylase deficiency (11β-OHD) is a rare form of CAH associated with low renin hypertension, hypokalemia, hyperandrogenemia and ambiguous genitalia in affected females. Herein we describe the clinical, hormonal and molecular characteristics of two Uzbekistan siblings with 11β-OHD and analyze the effects of a splicing mutation....
transfer matrix method (tmm) has been applied to analyze characteristics of semiconductor laser optical amplifiers. the input signal is sinusoidal modulating wave and we do not assume the modulating bias signal as well. we have shown that the distoration arises from gain modulation at low modulation frequencies, but in microwave modulation frequencies, the gain takes an average value and the re...
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