objective(s)cpg oligodeoxynucleotides (cpg odns) have been shown to have potent immunostimulatory adjuvant activity for a wide range of antigens. due to susceptibility of phosphodiester cpg odns (po cpg) to nuclease degradation, nuclease-resistant phosphorothioate cpg odns (ps cpg) were currently utilized in an in vivo model. in this study, according to some recently reported drawbacks with ps ...

diazinon is a moderately persistent organ phosphorus pesticide largely used in agriculture. thepurpose of this study was to evaluate the histopathological damages induced by diazinon in gills, kidney,spleen, and intestine tissues of rainbow trout, oncorhynchus mykiss. the fishes were exposed to sub-lethalconcentrations of diazinon (0.1 and 0.2 mg/l) for a period of 28 days. tissues analyzed by ...

diazinon is a moderately persistent organ phosphorus pesticide largely used in agriculture. thepurpose of this study was to evaluate the histopathological damages induced by diazinon in gills, kidney,spleen, and intestine tissues of rainbow trout, oncorhynchus mykiss. the fishes were exposed to sub-lethalconcentrations of diazinon (0.1 and 0.2 mg/l) for a period of 28 days. tissues analyzed by ...

Red blood cells (RBCs) can be cleared from circulation when alterations in their size, shape, and deformability are detected. This function is modulated by the spleen-specific structure of the interendothelial slit (IES). Here, we present a unique physiological framework for development of prognostic markers in RBC diseases by quantifying biophysical limits for RBCs to pass through the IES, usi...

OBJECTIVE The authors used a new surgical technique of near-total splenectomy (NTS) and report their experience. SUMMARY BACKGROUND DATA Total splenectomy is indicated for the management of patients with hereditary spherocytosis but may be complicated by severe infections and thromboembolic events. Studies have shown that partial or subtotal parenchymal resections can lead to excessive regene...

Animal models of colon cancer are widely used to understand the molecular mechanisms and pathogenesis of the disease. These animal models require a substantial investment of time and traditionally necessitate the killing of the animal to measure the tumor progression. Several in vivo imaging techniques are being used in both human clinics and preclinical studies, albeit at high cost and requiri...

Our findings show that the combination of splenic percussion and palpation will detect up to 88% of spleens considered to be enlarged on hepatic scintiscans. In other studies the correlation between clinical detection of splenomegaly and radiography or radioisotope scanning has been poor. Although as little as a 4000 increase in spleen size may be palpable, even massively enlarged spleens have ...