in this study cellular phosphatase activity, referred to as enzyme developed color (edc) assay, was used for an in vitro assessment of cell proliferation and cytotoxicity. optimum conditions were established and found to be 10 x103 cells / well at 37°c and 60 min incubation (for developing color). under the same conditions a direct correlation between optical density (00) and cell number was ob...

Laryngeal spindle cell (sarcomatoid) carcinomas are uncommon tumors, frequently misdiagnosed as reactive lesions or mesenchymal malignancies. The records of 187 patients with tumors diagnosed as laryngeal spindle cell (sarcomatoid) carcinoma were retrieved from the files of the Otorhinolaryngic Tumor Registry of the Armed Forces Institute of Pathology. There were 174 men and 13 women, 35–92 yea...

Background: Dermatofibrosarcoma protuberans a rare soft tissue tumour that involves the dermis, subcutaneous fat, and in cases muscle fascia. Case Report: 34 yr old female patient presented with history of swelling front right ear since 2 years, associated pain weeks , HRUSG neck reported as Neoplastic pathology FNAC benign spindle cell tumor. Patient underwent surgical excision tumour. Frozen ...

Lipoma of the cutaneous region is very common tumor. Most of cutaneous lipoma arises in the subcutaneous adipose tissue. When the tumor is composed exclusively mature lipocytes, the tumor is referred to as lipoma. When the tumor contains areas of capillary, it is called angiolipoma. When the tumor has rich fibrous tissue, it is called fibrolipoma. When the tumor consisted of spindle cells, it i...

BACKGROUND Synovial sarcoma is a rare soft tissue sarcoma in the head and neck region and parapharyngeal space. There is no previous cytologic report of synovial sarcoma of parapharynx. The cytologic and immunocytochemical findings of a parapharyngeal biphasic synovial sarcoma together with diagnostic pitfalls are described. CASE REPORT A 21-year-old girl presented with a 6-month history of p...

Mitotic spindle orientation in polarized cells determines whether they divide symmetrically or asymmetrically. Moreover, regulated spindle orientation may be important for embryonic development, stem cell biology, and tumor growth. Drosophila neuroblasts align their spindle along an apical/basal cortical polarity axis to self-renew an apical neuroblast and generate a basal differentiating cell....

CS: carcinosarcoma IHC: immunohistochemistry PCCS: primary cutaneous carcinosarcoma SCC: squamous cell carcinoma SCM: spindle cell melanoma SMA: smooth muscle actin SpSCC: spindle cell squamous cell carcinoma INTRODUCTION Malignancy can develop after exposure to ionizing radiation. Basal cell carcinoma, squamous cell carcinoma (SCC), and sarcoma associated with ionizing radiation have been repo...

Solitary fibrous tumor (SFT) is a neoplasm typically arising in the pleura. Yet, extrapleural cases have been described and are a common cause of diagnostic pitfalls, especially when met in unusual sites. We report the clinical and pathological features of a case of SFT arising in a rather unusual site, the urinary bladder, the seventh reported to date in the English literature and the first wi...

objective(s): in order to grow cells in a three-dimensional (3d) microenvironment, self-assembling peptides, such as puramatrix, have emerged with potential to mimic the extracellular matrix. the aim of the present study was to investigate the influence of the self-assembling peptide on the morphology, survival, proliferation rate, migration potential, and differentiation of human meningioma st...

Epithelial myoepthial carcinoma (EMEC) is rare, low grad tumor with epithelial and myoepithelial components frequent local recurrence, also called glycogen rich adenoma (clear cell pattern), myoepithelioma (spindle plamocytiod patterns), (if only differentiation marked cytologic atypia). Occurs most frequently in the major salivary glands accounts for approximately 1% of all gland neoplasms tha...