نتایج جستجو برای: spindle

تعداد نتایج: 26260  

رخشانی, ناصر , ستاره‌شناس, رویا,

ABSTRACT Intranodal palisaded myofibroblastoma (IPM) is a rare primary nonlymphoid Tumor of the lymph node, which can easily be mistaken for other spindle cell tumors. Intranodal palisaded myofibroblastoma is thought to arise from intranodal myofibroblasts. We describe a 13 year Iranian boy with IPM arose in the right arm. The tumor was well-demarcated and composed of a fascicular pr...

Journal: :Journal of cell science 1990
T I Baskin W Z Cande

Studies of mitotic spindle elongation in vitro using populations of diatom spindles visualized with immunofluorescence microscopy have shown that the two interdigitating half-spindles are driven apart by an ATP-dependent process that generates force in the zone of overlap between half-spindles. To characterize further the system responsible for spindle elongation, we observed spindle elongation...

2017
Masashi Yukawa Tomoki Kawakami Masaki Okazaki Kazunori Kume Ngang Heok Tang Takashi Toda

Accurate chromosome segregation relies on the bipolar mitotic spindle. In many eukaryotes, spindle formation is driven by the plus-end-directed motor kinesin-5 that generates outward force to establish spindle bipolarity. Its inhibition leads to the emergence of monopolar spindles with mitotic arrest. Intriguingly, simultaneous inactivation of the minus-end-directed motor kinesin-14 restores sp...

2015
Marina E. Crowder Jonathan R. Flynn Karen P. McNally Daniel B. Cortes Kari L. Price Paul A. Kuehnert Michelle T. Panzica Armann Andaya Julie A. Leary Francis J. McNally Fred Chang

Oocyte meiotic spindles orient with one pole juxtaposed to the cortex to facilitate extrusion of chromosomes into polar bodies. In Caenorhabditis elegans, these acentriolar spindles initially orient parallel to the cortex and then rotate to the perpendicular orientation. To understand the mechanism of spindle rotation, we characterized events that correlated temporally with rotation, including ...

Journal: :The Journal of Cell Biology 1999
Linda M. Woods Craig A. Hodges Esther Baart Sean M. Baker Michael Liskay Patricia A. Hunt

In mouse oocytes, the first meiotic spindle is formed through the action of multiple microtubule organizing centers rather than a pair of centrosomes. Although the chromosomes are thought to play a major role in organizing the meiotic spindle, it remains unclear how a stable bipolar spindle is established. We have studied the formation of the first meiotic spindle in murine oocytes from mice ho...

Journal: :iranian biomedical journal 0
chinh chung doan ngoc trung doan quang huy nguyen minh hoa nguyen minh si do van dong le

background: kinesin spindle protein (ksp) plays a critical role in mitosis. inhibition of ksp function leads to cell cycle arrest at mitosis and ultimately to cell death. the aim of this study was to suppress ksp expression by specific small-interfering rna (sirna) in hep3b cells and evaluate its anti-tumor activity. methods: three sirna targeting ksp (ksp-sirna #1-3) and one mismatched-sirna (...

2016
Jinxue He Zhong Zhang Meng Ouyang Fan Yang Hongbo Hao Kristy L. Lamb Jingyi Yang Yuxin Yin Wen H. Shen

Architectural integrity of the mitotic spindle is required for efficient chromosome congression and accurate chromosome segregation to ensure mitotic fidelity. Tumour suppressor PTEN has multiple functions in maintaining genome stability. Here we report an essential role of PTEN in mitosis through regulation of the mitotic kinesin motor EG5 for proper spindle architecture and chromosome congres...

Journal: :Developmental cell 2010
Marion Ségalen Christopher A Johnston Charlotte A Martin Julien G Dumortier Kenneth E Prehoda Nicolas B David Chris Q Doe Yohanns Bellaïche

The Frizzled receptor and Dishevelled effector regulate mitotic spindle orientation in both vertebrates and invertebrates, but how Dishevelled orients the mitotic spindle is unknown. Using the Drosophila S2 cell "induced polarity" system, we find that Dishevelled cortical polarity is sufficient to orient the spindle and that Dishevelled's DEP domain mediates this function. This domain binds a C...

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