We recorded in the CA1 region from hippocampal slices of prion protein (PrP) gene knockout mice to investigate whether the loss of the normal form of prion protein (PrPC) affects neuronal excitability as well as synaptic transmission in the central nervous system. No deficit in synaptic inhibition was found using field potential recordings because (i) responses induced by stimulation in stratum...

SARS-CoV-2 is an RNA coronavirus responsible for Acute Respiratory Syndrome (COVID-19). In January 2021, the re-occurrence of COVID-19 infection was at its peak, considered second wave epidemics. initial stage, it a double mutant strain due to two significant mutations observed in their Spike protein (E484Q and L452R). Although first detected India later on, spread several countries worldwide, ...

Because of the catastrophic consequences COVID-19 on world population, there should be novel­ interventions to handle ongoing infections and daily death cases. The aim current study is examine effectiveness HBV (Honeybee venom) proteins spike protein RBD by in silico tools. sequences 5 were used for homology modeling Phyre 2. generated models employed protein-protein docking against Omicron Spi...

OBJECTIVE The spike (S) protein of porcine hemagglutinating encephalomyelitis virus (PHEV) may mediate infection by binding to a cellular neural cell adhesion molecule (NCAM). This study aimed to identify the crucial domain of the S1 subunit of the S protein that interacts with NCAM. METHODS Three truncated segments (S(1-291), S(277-794) and S(548-868)) of the S gene of PHEV and the NCAM gene...

Cytotoxicity was induced in cells mimicking SARS-CoV-2 infection by a 225 Ac-radiolabeled antibody that targets the RBD2 of spike protein.

The transcribed mRNA is 14,294 bp (Cohen et al., 1993). An alternative transcript for unc-52, the homologous gene to perlecan in C. elegans, has been reported (Spike et al., 2002). In addition, a human alternative transcript was submitted to the NCBI (Accession Q8TEU3_HUMAN) as a sequence for a short version variant, miniperl, encoding a 240 amino acid protein of 25.942 kD. Expression of HSPG2 ...

Various strains of mouse hepatitis virus (MHV) exhibit different pathogenic phenotypes. Infection with the A59 strain of MHV induces both encephalitis and hepatitis, while the highly neurovirulent JHM strain induces a fatal encephalitis with little, if any, hepatitis. The pathogenic phenotype for each strain is determined by the genetic composition of the viral genome, as well as the host immun...

to study the effects of urea foliar spray at different plant growth stages on grain yield and protein percentage of two dryland wheat varieties of sardari and azar 2, an experiment was conducted in east mangor agricultural station of mahabad in 2007– 2008. the experiment design was split plot based on randomized complete block design with three replications. treatments were 50 gr×10 m-2 n as ur...

drought stress is one of the most important environmental stresses that affect yield of bread wheat strongly. considering that the yield achieved with the interaction of a large number of plant traits and environment, so the morphological and agronomical traits, can serve as selection criteria under environmental conditions. by genetic analysis and estimation of inheritance and mode of gene act...

  Toxoplasma gondii contain various immunogenic antigens. The most important Toxoplasma antigens are somatic and excreted/secreted antigens. Rhoptry proteins are known as excreted/secreted antigens. These antigens have been proposed as a vaccine candidate against toxoplasmosis. The main objective of the present work was cloning rhoptry protein1 (ROP1) Gene of Toxoplasma gondii (RH) in a cloning...