The oxidative phosphorylation system (OXPHOS) consists of five multi-enzyme complexes, Complexes I-V, and is a key component of mitochondrial function relating to energy production, oxidative stress, cell signaling and apoptosis. Defects or a reduction in activity in various components that make up the OXPHOS enzymes can cause serious diseases, including neurodegenerative disease and various me...

It is not the possession of truth, but the success which attends the seeking after it, that enriches the seeker and brings happiness to him. Paraschiv and Ute Schad for all the help they gave me, Reinhold Weber for the organization and expert group leading in the Swiss Alps. Livia and Ioana for their support and the wonderful time spent together. Last but not least I wish to thank and to expres...

Disulfide crosslinks are ubiquitous in natural peptides and proteins, providing rigidity to polypeptide scaffolds. The assignment of disulfide connectivity in multiple crosslinked systems is often difficult to achieve. Here, we show that rapid unambiguous characterisation of disulfide connectivity can be achieved through direct mass spectrometric CID fragmentation of the disulfide intact polype...

Computational proteomics is one of today’s foremost challenges in bioinformatics with applications in fields as diverse as toxicology, diagnostics, or target identification and validation. The current de-facto standard for high-throughput proteomics studies, HPLC-MS, is capable of generating huge amounts of data for a single analysis: the LC-MS maps, which can be thought of as a collection of o...

Inorganic mass spectrometric methods are widely used for the multielemental determination of elements at the trace and ultratrace level in high-purity materials (e.g., conducting, semiconducting and nonconducting solid samples, high-purity water, organic solutions and solvents). Inductively coupled plasma mass spectrometry (ICP-MS), laser ablation inductively coupled plasma mass spectrometry (L...

Unknown compounds in polar fractions of Arabidopsis thaliana crude leaf extracts were identified on the basis of calculations of elemental compositions obtained from gas chromatography/low-resolution quadrupole mass spectrometric data. Plant metabolites were methoximated and silylated prior to analysis. All known peaks were used as internal references to construct polynomial recalibration curve...

Dimers of inclusion complexes were formed from a new cryptand and viologens (paraquats) driven by dipole-dipole and face-to-face pi-stacking interactions as shown by mass spectrometric characterization and X-ray analysis.

Geraniin and gallic acid were isolated from the alcohol extract of the aerial parts of Erodium glaucophyllum (Geraniaceae). The identity of the compounds was verified through different physical and spectrometric methods. The antibacterial and antifungal activity of geraniin is presented.