Background Diastolic dysfunction is traditionally believed to be the first subclinical manifestation of diabetic cardiomyopathy (DCM), leading systolic and then overt heart failure. However, in last few years, several studies suggested that measured by speckle-tracking echocardiography (STE) may appear ahead diastolic dysfunction. In this review, main endpoint show whether myocardial appears im...

Label free tracking of small bio-particles such as proteins or viruses is great utility in the study biological processes, however experiments are frequently hindered by weak signal strengths and a susceptibility to scattering impurities. To overcome these problems we here propose novel technique leveraging enhanced sensitivity both interferometric detection strong field confinement surface pla...