نتایج جستجو برای: specific antigens
تعداد نتایج: 1118456 فیلتر نتایج به سال:
Cancer testis antigens (CTAs), a large family of tumor-associated and immunogenic antigens expressed in human tumors of various histological origins, are highly restricted to the testis and trophoblast. CTAs have been identified as potent targets for tumor-specific immunotherapeutic advances and have immensely lead to the development of different clinical trials of CTA-based vaccine therapy bec...
SUMMARY Antigens from a rat astrocytoma cell line were compared with those from normal rat liver and normal rat brain by the immunodiffusion and immunoelectrophoresis techniques. Antigens that appeared to be specific to the tumor cells were observed. Although these were predominantly in the soluble fraction, a small but distinct amount of the antigens were found to be membrane bound. The existe...
OBJECTIVE Immune complexes (ICs) trigger humoral immune responses. Therefore, the identification of constituent antigens within ICs would have very different clinical significance than identification of free antigens. DESIGN AND METHODS Here, we applied immune complexome analysis of serum to the study of seven major autoimmune diseases-anti-neutrophil cytoplasmic antibody-associated vasculiti...
Several studies in mouse model of invasive aspergillosis (IA) and in healthy donors have shown that different Aspergillus antigens may stimulate different adaptive immune responses. However, the occurrence of Aspergillus-specific T cells have not yet been reported in patients with the disease. In patients with IA, we have investigated during the infection: a) whether and how specific T-cell res...
The antigenic properties of the VH region of immunoglobulin heavy chains were studied by means of a fragment corresponding to the variable part of the heavy chain of an IgG3 myeloma protein (KUP) and an antiserum made against this fragment. By hemagglutination, hemagglutination inhibition, and immunofluorescence techniques, it was shown that the anti-VH antiserum detected three sets of antigens...
Diagnostic tests for leprosy are limited, especially to identify early cases. We performed active case findings of validate three potential antigen candidates and one molecular target. Cases were diagnosed by characteristic skin lesions, nerve enlargement, or sensation loss. Serum samples obtained from all subjects tested ELISA assess antibody titers Mycobacterium leprae specific antigens: NDO-...
introduction: toxoplasma gondii is a protozoan parasite which is globally prevalent in human and animals. toxoplasma infection is commonly asymptomatic, but can cause serious medical problems in immunocompromised individuals and in fetus. recombinant antigens of the parasite may be helpful in diagnosing the infection more precisely. the goal of this study was to construct and evaluate the funct...
IT has been shown that human cornea carries blood-group specific antigens corresponding to those of red blood cells (Nelken, Michaelson, Nelken, and Gurevitch, 1956, 1957) and the clinical significance of these findings has been discussed by various authors (Havener, Stine, and Weiss, 1958; Mehri, Becker, and Oglesby, 1959). Sudden clouding of the graft, maladie du greffon, could be produced ex...
The use of defined protein and peptide antigens can overcome specificity limitations of purified protein derivatives in the detection of bovine tuberculosis when the antigens are used in blood-based tests. Since the use of these specific antigens as skin test reagents could have practical advantages, we investigated the potential of Mycobacterium bovis-specific antigens to stimulate delayed-typ...
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