Soy isoflavone is an attractive source of functional cosmetic materials with anti-wrinkle, whitening and skin hydration effects. After consumption, the majority of soy isoflavones are converted to their metabolites in the human gastrointestinal tract. To understand the physiological impact of soy isoflavone on the human body, it is necessary to evaluate and address the biological function of it...

Data regarding convenient, valid methods for measuring U.S. isoflavone intake are limited. We evaluated a soy food questionnaire (SFQ), the Willett food frequency questionnaire (FFQ), and overnight urine samples relative to excretion in 24-h urine samples. We also described intake among women in a high-risk program for breast or ovarian cancer. Between April 2002 and June 2003, 451 women aged 3...

An eight-week feeding trial was conducted to evaluate the effects of soy isoflavone and saponin on growth performance, intestinal structure, immunity gut microbiota community rice field eel Monopterus albus (initial weight 20.12 ± 0.15 g). Six isonitrogenous isolipidic experimental feeds were formulated, including a positive control (55% fish meal, FM), negative (28.6% 37.2% soybean SBM) basic ...

BACKGROUND Bifidobacterium species, including Bifidobacterium pseudocatenulatum, are among the dominant microbial populations of the human gastrointestinal tract. They are also major components of many commercial probiotic products. Resident and transient bifidobacteria are thought to have several beneficial health effects. However, our knowledge of how these bacteria interact and communicate w...

Soy protein and isoflavones (phytoestrogens) have gained considerable attention for their potential role in improving risk factors for cardiovascular disease. This scientific advisory assesses the more recent work published on soy protein and its component isoflavones. In the majority of 22 randomized trials, isolated soy protein with isoflavones, as compared with milk or other proteins, decrea...

Incidence rates of colorectal cancer are relatively low in Asian populations, in which soy foods are commonly consumed. Soybeans and soy foods are an almost exclusive source of isoflavone intake. In in vitro studies, isoflavones have been shown to have various anticarcinogenic properties such as inhibition of protein tyrosine phosphorylation, induction of apoptosis, antiangiogenesis, and inhibi...

BACKGROUND The anticarcinogenic and antiatherogenic properties of soy have been demonstrated in experimental studies. To evaluate the relationship between soy product intake and mortality from several types of cancer and heart disease, an ecological analysis was performed in 47 prefectures in Japan. METHODS Age-standardized mortality rates for heart disease and stomach, colorectal, lung, brea...

Soybean seeds contain large amounts of isoflavones or phytoestrogens such as genistein, daidzein, and glycitein that display biological effects when ingested by humans and animals. In seeds, the total amount, and amount of each type, of isoflavone varies by 5 fold between cultivars and locations. Isoflavone content and quality are one key to the biological effects of soy foods, dietary suppleme...

Consumption of soy protein has been associated with altered risk of developing endocrine-regulated cancers. This study was designed to assess the independent effect of soy relative to animal protein and soy-derived isoflavones on circulating estrogen and androgen concentrations in postmenopausal women and older men. Forty-two subjects (> 50 yr) with low-density lipoprotein cholesterol levels of...

The inhibitory activity of 3 soy isoflavones (daidzein, genistein and glycitein) and their glycosides (daidzin, genistin and glycitin) on mammalian DNA polymerases (pols) and topoisomerases (topos) was investigated. Of the compounds tested, only genistein selectively inhibited human topo II activity and had an IC50 value of 37.5 µM. These isoflavones had no effect on the activity of human topo ...