Nerve growth factor-β (NGF) is essential for the correct development of the nervous system. NGF exists in both a mature form and a pro-form (proNGF). The two forms have opposing effects on neurons: NGF induces proliferation, whereas proNGF induces apoptosis via binding to a receptor complex of the common neurotrophin receptor (p75NTR) and sortilin. The overexpression of both proNGF and sortilin...

Efforts at reducing cardiovascular events rely on the accurate identification of individuals at risk. Unfortunately, patients who experience cardiovascular events often have a paucity of traditional factors predictive of cardiovascular disease (CVD) to facilitate recognition of risk. In this regard, measurement of circulating biomarkers has been examined as an option for assessing risk for card...