نتایج جستجو برای: sonogashira coupling reaction

تعداد نتایج: 556603  

Journal: :Chemical & pharmaceutical bulletin 2012
Maiko Hamada Kunitomo Adachi Hidemasa Hikawa Yuusaku Yokoyama

A concise synthesis of a useful intermediate 10 for the preparation of fingolimod (FTY-720) analogs was achieved by utilizing a chemoselective Sonogashira reaction of trihalobenzene 12 with alkyne 13. The reaction proceeded with high selectivity to give alkyne 11 containing the dihalobenzene moiety in good yield. Compound 11 was converted into intermediate 10 by hydrogenation without reduction ...

Journal: :The Journal of organic chemistry 2006
Frank Seela Xiaohua Peng

[reaction: see text] The Silyl-Hilbert-Johnson reaction as well as the nucleobase-anion glycosylation of a series of 7-deazapurines has been investigated, and the 7-functionalized 7-deazapurine ribonucleosides were prepared. Glycosylation of the 7-halogenated 6-chloro-2-pivaloylamino-7-deazapurines 9b-d with 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (5) gave the beta-D-nucleosides 11b-d (73...

Journal: :Chemical communications 2016
Mark M Maturi Gaku Fukuhara Koichiro Tanaka Yuko Kawanami Tadashi Mori Yoshihisa Inoue Thorsten Bach

A chiral template was constructed from 7-ethynyl-1,5,7-trimethyl-3-azabicyclo[3.3.1]nonan-2-one by Sonogashira cross-coupling with 4,4''-diiodoterphenyl and was shown to bind the title compound strongly by hydrogen bonding resulting in enantioselectivities of up to 55% enantiomeric excess (ee) in the [4+4] anthracene photodimerization.

Journal: :Organic & biomolecular chemistry 2011
Jingyu Yang Chengyu Wang Xin Xie Hongfeng Li Ende Li Yanzhong Li

An efficient palladium/copper-catalyzed approach to the synthesis of highly substituted 3-formyl furans from the reactions of readily available α-bromoenaminones with terminal alkynes has been developed. This methodology was realized by the cascade reactions of Sonogashira coupling and the subsequent intramolecular cyclization.

Journal: :Chemical communications 2005
Jonathan C Collings Alexander C Parsons Laurent Porrès Andrew Beeby Andrei S Batsanov Judith A K Howard Donocadh P Lydon Paul J Low Ian J S Fairlamb Todd B Marder

Donor-acceptor phenylene ethynylene systems containing the 6-methylpyran-2-one group, synthesized via classic or microwave-assisted Sonogashira cross-coupling, exhibit pronounced solvatochromism in fluorescence suggesting a highly polar excited state; 4-[4-(4-N,N-dihexylaminophenylethynyl)phenylethynyl]-6-methylpyran-2-one has a fluorescence quantum yield >0.9 in cyclohexane.

Journal: :Organic & biomolecular chemistry 2015
Anasuyamma Uruvakili G Gangadhararao K C Kumara Swamy

One-pot synthesis of highly substituted norbornadienes/norbornenes via gold-catalysed dehydrative cyclisation of alkynyldienols, followed by intermolecular [4 + 2] cycloaddition of in situ generated cyclopentadiene and activated alkynes/alkenes is described. The precursors, alkynyldienols, are obtained via sequential Sonogashira cross-coupling of 3-bromoenals, alkyne addition and reduction. Yie...

Journal: :Organic & biomolecular chemistry 2010
Roberto Sanz Verónica Guilarte Nuria García

A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.

Journal: :Biomaterials Science 2021

Four novel transition metal-carborane photosensitisers were prepared by Sonogashira cross-coupling of 1-(4-ethynylbenzyl)-2-methyl-o-carborane (A-CB) with halogenated Ru(ii)- or Ir(iii)-phenanthroline complexes.

Journal: :Chemical communications 2015
Subhashini Selvaraju K A Niradha Sachinthani RaiAnna A Hopson Frederick M McFarland Song Guo Arnold L Rheingold Toby L Nelson

An eumelanin-inspired core derived from the natural product, vanillin (vanilla bean extract) was utilized for the synthesis of eumelanin-inspired small molecules and polymer via Sonogashira cross coupling. The materials demonstrate that the methyl 4,7-dibromo-5,6-dimethoxy-N-methyl-1H-indole-2-carboxylate core can serve as a new building block for organic semiconductors.

Journal: :Chemical communications 2006
Md Taifur Rahman Takahide Fukuyama Naoya Kamata Masaaki Sato Ilhyong Ryu

A low pressure microflow system was developed for palladium-catalyzed multiphase carbonylation reactions in an ionic liquid. The microflow system resulted in superior selectivity and higher yields in carbonylative Sonogashira coupling and amidation reactions of aryl iodides compared to the conventional batch system.

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