The main advantage of sonodynamic therapy (SDT), the combining ultrasound with a sonosensitizer, over photodynamic (PDT) is that penetrates deeper into tissues to activate which offers noninvasive for tumors in site-oriented approach. In this study, we synthesized two symmetrical phenothiazine derivatives methyl groups MB (methylene blue) have been replaced by hexyl and hydroxyethyl chains, nam...

How to make cancer treatment more efficient and enhance the patient’s outcome? By multimodal therapy, theranostics, or personalized medicine? These are questions asked by scientists doctors worldwide. However, finding new unique approaches options for as well selective therapeutics is very challenging. More frequently, researchers “go back in time” use already known well-described compounds/dru...

  ABSTRACTBackground : In order to quantify effects of ultrasound irradiation parameters under therapeutic condition, especially sonodynamic therapy, it is initially necessary to evaluate inertial cavitation activity in vitro conditions therefore, in this study, the effect of 1 MHz low level ultrasound based on °OH radicals generated by acoustic inertial cavitation in aqueous solution was monit...

BackgroundIn vascular surgery, neointimal hyperplasia is a significant clinical phenomenon because it reduces the long-term effectiveness of surgical and endovascular procedures. We devised an experimental sonodynamic therapy protocol tested its efficacy on reduction in this study, which diagnostic B-mode ultrasound paired with focused-ultrasound goal greater safety.Methods ResultsGolden Syrian...