Background: The RenuvaTM System is a dietary supplement sold to prevent symptoms of age-related growth hormone decline. Objective: Test the ability of the RenuvaTM System to increase growth hormone (GH) and insulin-like growth factor-1 (IGF-1). Methods: The RenuvaTM System is a two-part dietary supplement to maintain a healthy endocrine system. The “Generator Drink” contains amino acids and nic...

The effects of GH injections on the concentrations of plasma hormones and metabolic substrates in pigs were studied under various nutritional conditions. In experiment 1, four pigs (Large white, barrows, 108 days old) were maintained at three feeding levels: (1) high level (8,501 +/- 46 kcal/ day), (2) maintenance level (2,104 +/- 44 kcal/day), and (3) fasting (last meal was on day -2). The bov...

Chronic exposure to growth hormone (GH) was related to the desensitization of the JAK2/STAT5 signaling pathway in liver, as demonstrated in cells, female rats, and transgenic mice overexpressing GH. The cytokine-induced suppressor (CIS) is considered a major mediator of this desensitization. Pregnancy is accompanied by an increment in GH circulating levels, which were reported to be associated ...

Using an explant culture system, we have demonstrated that human somatotropes respond to growth hormone releasing factor (GRF) and somatostatin (SRIF) from as early as 9.5 weeks of fetal age. Responsiveness to GRF increases significantly as a function of age up to midgestation while SRIF inhibition of basal growth hormone (GH) release does not change. SRIF has little effect on GRF-stimulated GH...

CONTEXT The prevalence of scoliosis in children with Prader-Willi syndrome (PWS) is 30-80%, depending on age. Although reports about effects of GH treatment on scoliosis in children with PWS are limited, scoliosis is generally considered a contraindication for GH treatment. OBJECTIVE The aim was to study the effects of GH treatment on the onset of scoliosis and curve progression in children w...

Similar to the 2006 consensus statement on the standardization of growth hormone (GH) assays (1 ), the guidelines regarding improvement of assay comparability in a recent consensus statement in Clinical Chemistry (2 ) are limitedto the recommendation to the recommendation of common use of the Second International Standard for Somatropin (IS 98/574), although it is recognized that discrepancies ...

Adult fed and starved Warren chickens, 2 yr of age, and approaching the end of the second laying year, were injected iv with 1 of the following products: 10 micrograms of thyrotropin releasing hormone (TRH); 100 micrograms of bovine thyrotropin (bTSH); 100 micrograms of ovine growth hormone (oGH); saline. The influence on plasma concentrations of thyroxine (T4), triiodothyronine (T3) or chicken...

OBJECTIVES To examine quality of life (QoL) measured by a utility-weighted index in GH-deficient adults on GH replacement and analyse the impact of demographic and clinical characteristics on changes in utilities during treatment. DESIGN Utilities for items in the QoL-Assessment of Growth Hormone Deficiency in Adults (QoL-AGHDA(utility)) were estimated based on data obtained from the general ...

Deficiency of growth hormone (GH) in adults results in a syndrome characterized by decreased muscle mass and exercise capacity, increased visceral fat, impaired quality of life, unfavorable alterations in lipid profile and markers of cardiovascular risk, decrease in bone mass and integrity, and increased mortality. When dosed appropriately, GH replacement therapy (GHRT) is well tolerated, with ...

The results of these studies suggested that the growth hormone might play a role in the management of visceral fat accumulation associated with HIV. Analysis of the treatment effect sizes in the published studies show that the effects of various doses of rhGH on trunk fat fit a dose-response characteristic.