The metabolism and macromolecular binding of the carcin ogen benzo(a)pyrene[B(a)P]and its relativelyinert structural isomer benzo(e)pyrene [B(e)P1 have been studied in order to determine if a metabolic basis exists for their very different biological activities. B(a)P and B(e)P are metabolized by hamster embryo cells to organic solvent-soluble and water-soluble metabolites. Signifi cant quantit...

The metabolism and macromolecular binding of the carcin ogen benzo(a)pyrene[B(a)P]and its relativelyinert structural isomer benzo(e)pyrene [B(e)P1 have been studied in order to determine if a metabolic basis exists for their very different biological activities. B(a)P and B(e)P are metabolized by hamster embryo cells to organic solvent-soluble and water-soluble metabolites. Signifi cant quantit...

REFERENCES 1. Panicker SR, Mehta-D’souza P, Zhang N, Klopocki AG, Shao B, McEver RP. Circulating soluble P-selectin must dimerize to promote inflammation and coagulation in mice. Blood. 2017;130(2):181-191. 2. Ushiyama S, Laue TM, Moore KL, Erickson HP, McEver RP. Structural and functional characterization of monomeric soluble P-selectin and comparison with membrane P-selectin. J Biol Chem. 199...

in order to investigate the effect of phosphorus fertilizer and spraying fe chellat in micronutrients absorption rate, rate of proline and soluble carbohydrates in bread wheat and some of its ancestral species in dryland condition, a factorial experiment was conducted with three factors consist of: p fertilizer (in two levels), spraying fe chellat (in two levels) and different species of wheat ...

abstract in order to study the effect of different water potential on anethum graveolens two experiments were conducted for germination and vegetative stages. this study was carried out as a factorial experiment based on completely randomized design with three replications. in the first experiment, response of dill seeds germination to levels of drought stress including to drought potentials ze...

Patients with multiple myeloma commonly develop focal osteolytic bone disease, as well as generalised osteoporosis. The mechanisms underlying the development of osteoporosis in patients with myeloma are poorly understood. Although disruption of the RANKL/OPG pathway has been shown to underlie formation of focal osteolytic lesions, its role in the development of osteoporosis in myeloma remains u...

BACKGROUND Preeclampsia is a life-threatening pregnancy syndrome of uncertain origin. To elucidate the pathogenesis, we evaluated the temporal relationships between changes in vascular function and circulating biomarkers of angiogenic activity before and after the onset of preeclampsia and gestational hypertension. METHODS AND RESULTS Maternal mean arterial pressure, uterine artery pulsatilit...

BLyS is involved in CLL biology and its low soluble serum levels related to a shorter time to first treatment (TFT). TACI is a BLyS receptor and can be shed from cells' surface and circulate in soluble form (sTACI). We investigated the impact of serum BLyS and sTACI levels at diagnosis in CLL patients and their relationship with disease parameters and patients' outcome. Serum BLyS was determine...

background: leishmania major lmsti1 is a conserved protein among different species of leishmania, and expressed in both amastigote and promastigote forms of l. major life cycle. it has previously been expressed in bacterial systems. m aterials and methods: to express lmsti1 in the methylotrophic yeast         pichia pastoris ( p. pastoris ), the shuttle vector ppicza containing gene lmsti1 was ...

Background—Preeclampsia is a life-threatening pregnancy syndrome of uncertain origin. To elucidate the pathogenesis, we evaluated the temporal relationships between changes in vascular function and circulating biomarkers of angiogenic activity before and after the onset of preeclampsia and gestational hypertension. Methods and Results—Maternal mean arterial pressure, uterine artery pulsatility ...