نتایج جستجو برای: soluble cd30
تعداد نتایج: 90963 فیلتر نتایج به سال:
Primary cutaneous anaplastic large T-cell lymphoma CD30+ is a rare lymphoma, which belongs to the group of lymphoproliferations CD30+. It characterized by an excellent prognosis and treatment therefore not very aggressive. However, its histological molecular characteristics have many similarities with lymphoproliferative diseases whose completely different. For this reason, it important study p...
With an increasing number of clinical trials looking at combination therapies in cancer, potential drug–drug interactions require particular attention. One such instance is the treatment of CD30þ tumors after previous vorinostat (SAHA; suberoylanilide hydroxyamic acid) failure with the anti-CD30 antibody–drug conjugate brentuximab vedotin. Using B-, T-, and natural killer (NK)–cell lines in vit...
PURPOSE This study was undertaken to evaluate the effects of MDX-1401, a nonfucosylated fully human monoclonal antibody that binds to human CD30, and to determine whether it exhibits greater in vitro and in vivo activity than its parental antibody. EXPERIMENTAL DESIGN Assays measuring antibody binding to CD30-expressing cells and FcgammaRIIIa (CD16) transfectants as well as antibody-dependent...
CD30, a member of the tumor necrosis factor receptor superfamily, is a transmembrane glycoprotein receptor consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. CD30 has emerged as an important molecule in the field of targeted therapy because its expression is generally restricted to specific disease types and states. The major cancers with elevated CD30 e...
The CD30 surface molecule is a recently identified member of the tumor necrosis factor/nerve growth factor receptor superfamily. Within the cytoplasmic signal transducing domain, CD30 shares no significant homology to other members of this family. Signaling events engaged via CD30 are still unknown. We here identify the NF-kappabeta transcription factor as a target of the CD30-induced signal pa...
چکیده سابقه و هدف: برای تشخیص و افتراق لنفوم هوچکین از سایر لنفوم ها از مارکرهای ایمونوهیستوشیمی به خصوص cd15 و cd30 استفاده می گردد. با توجه به آمارهای متفاوت فراوانی مارکرهای فوق وعدم اطلاع از وضعیت در کشور و به منظور تعیین شیوع ایمونوراکتیویتی برای مارکرهای cd15و cd30 در بیماران ایرانی مبتلا به لنفوم هوچکین کلاسیک این تحقیق انجام گرفت. روش بررسی: تحقیق به روش مقطعی بر روی کلیه بیماران با تشخ...
Originally, expression of the CD30 antigen was shown to be typical of the tumor cells of Hodgkin disease and of anaplastic large cell lymphomas. In reactive lymphoid tissue, CD30 is expressed only in a small population of activated lymphoid blasts. Since then, several reports have been published describing CD30 expression in non lymphoid tissues and neoplasms, such as embryonal carcinomas, semi...
Lymphomatoid papulosis (LyP) represents an intriguing cutaneous T-cell lymphoproliferative disorder with a histologic appearance resembling malignant lymphoma. This finding strongly contrasts with the benign clinical course of the disease. However, in 10% to 20% of cases, LyP can precede, coexist with, or follow malignant lymphoma. In these cases, the same T-cell population has been shown to be...
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