BACKGROUND Cardioprotective and other clinical benefits of long-chain n-3 polyunsaturated fatty acids (PUFA) are inversely related to dietary intake and hence blood content. We therefore investigated, in the first study of its kind, the blood content and distribution of these fatty acids in a large representative population of US hemodialysis patients. METHODS Frozen sera were obtained from 4...

This study examined measures of clean cookstove adoption after improved solid fuel stove programmes in three geographically and culturally diverse rural Andean settings and explored factors associated with these measures. A questionnaire was administered to 1200 households on stove use and cooking behaviours including previously defined factors associated with clean cookstove adoption. Logistic...

The extent to which a drug inhibits a target responsible for a therapeutic effect is a more rational primary endpoint for dose-finding studies of more selective anticancer drugs than the conventional endpoint of dose-limiting toxicity (DLT) used for cytotoxic agents. An adaptive phase I trial design incorporating maximum target inhibition as the primary endpoint was developed to define the opti...

This report proposes a standard method to characterize variability and sensitivity of functional neuroimaging experiments. Most functional neuroimaging analyses result in statistic images of signal-to-noise. However, it is essential to examine both signal and noise individually, to characterize sensitivity and to identify artifacts. Confidence intervals simultaneous convey signal and noise but ...

The difference between the disease rates of two groups, one exposed and one not exposed to a suspected aetiological factor, is a useful measure of the risk associated with the factor. This measure is of most interest when the association is considered causal, and has been termed the attributable risk (MacMahon and Pugh, 1970). Expressed as a percentage of the total disease rate in a group (the ...