We present a microstructure-based dual-core dispersion-compensating fiber (DCF) design for dispersion compensation in long-haul optical communication links. The design has been conceptualized by combining the all-solid dual-core DCF and dispersion-compensating photonic crystal fiber. The fiber design has been analyzed numerically by using a full vectorial finite difference time domain method. W...

PURPOSE The aim of the present investigation was preparation and characterization of sirolimus solid dispersions by solvent evaporation technique to improve its dissolution properties. METHODS Polyvinylpyrrolidone (PVP), Poloxamer 188 and Cremophore RH40 were used to prepare the solid dispersions of sirolimus. In vitro dissolution study using USP type I apparatus, were performed in distilled ...

Two all-solid glass photonic crystal fibers with all-normal dispersion profiles are evaluated for coherent supercontinuum generation under pumping in the 2.0 μm range. In-house boron-silicate and commercial lead-silicate glasses were used to fabricate fibers optimized for either flat dispersion, albeit with lower nonlinearity, or with larger dispersion profile curvature but with much higher non...

Classical molecular dynamics simulations are performed on LiF in the framework of the polarizable ion model. The overlap repulsion and polarization terms of the interaction potential are derived on a purely non-empirical, first-principles basis. For the dispersion, three cases are considered: a first one in which the dispersion parameters are set to zero and two others in which they are include...

objective(s) the purpose of the present study was to use the solid dispersion (sd) technique to improve the dissolution rates of indomethacin (imc). materials and methods imc solid dispersions in pvp k30 and isomalt (galen iq 990) were prepared using the solvent evaporation technique and a hot melt method in weight ratios of 2, 10 and 30% (imc:pvp). solid dispersions and physical mixtures were ...

Solid dispersions is an efficient means of improving the dissolution rate and hence the bioavailability of a range of poorly soluble drugs. This article reviews the various types of solid dispersion, preparation techniques for solid dispersion and compiles some of the recent technologies. Some of the practical aspects to be considered for the preparation of solid dispersions, such as selection ...

AIM To enhance the aqueous solubility of olanzapine by using the Solid dispersion technique. Solid dispersions of olanzapine were prepared by the dispersion method using using PGS and SSG as carriers. Drug-carrier ratios such as 1 : 1, 1 : 2, 1 : 4, 1 : 6, 1: 8 and 1 : 10 were tried for optimization. Characterization was done by phase solubility, in-vitro release, saturation solubility, permeat...

The aim of this study was to prepare solid dispersions of chlordiazepoxide techniques to improve its dissolution rate. To this end, three techniques namely, two solvent methods and co-grinding technique were used. Solid dispersions of chlordiazepoxide in polyvinylpyrrolidone (PVP), Eudragit E100, Mannitol and Sorbitol with two different ratios of drug to carrier (5:5 and 1:9) were prepared. The...

Diffusion-controlled-creep processes are used to assess the creep behavior of dispersion and solute hardened materials at coarse and fine grain sizes. It is shown that the creep behavior of a dispersion strengthened (DS) Al–Mg alloy is similar to the creep behavior of pure Al–Mg alloys. Both materials show dislocation climb and dislocation solute-drag contributions to creep. It is shown that th...

The solubility behavior of drugs remains one of the most challenging aspects in the formulation development. Although there was a great interest in solid dispersion systems during the past four decades to increase solubility by improving dissolution rate and bioavailability of poorly soluble drugs; there commercial use has been very limited, primarily because of manufacturing difficulties and v...