The Na(+)/I(-) symporter (NIS) is a key plasma membrane glycoprotein that mediates active I(-) transport in the thyroid gland (Dai, G., Levy, O., and Carrasco, N. (1996) Nature 379, 458-460), the first step in thyroid hormone biogenesis. Whereas relatively little is known about the mechanisms by which thyrotropin (TSH), the main hormonal regulator of thyroid function, regulates NIS activity, po...

In Saccharomyces cerevisiae, the fermentation rate and ability to complete sugar transformation process depend on glucose fructose transporter set-up. Hexose transport mainly occurs via facilitated diffusion carriers these are encoded by HXT gene family GAL2. addition, FSY1, coding a fructose/H+ symporter, was identified in some wine strains. This little-known could be relevant last part of whe...

Transport proteins of the neurotransmitter sodium symporter (NSS) family regulate the extracellular concentration of several neurotransmitters in the central nervous system. The only member of this family for which atomic-resolution structural data are available is the prokaryotic homologue LeuT. This protein has been used as a model system to study the molecular mechanism of transport of the N...