Background : Inhibition of histone deacetylase (HDAC) was reported to suppress cardiac hypertrophy and fibrosis in various hypertrophic animal models. However, the HDAC expression profile and HDAC enzyme activity have not yet been investigated in DOCA-salt hypertensive rats. Methods : Unilaterally nephrectomized rats were implanted with DOCA strips. DOCA-salt rats then received a control diet w...

A girl aged 1 year died of acute haemorrhagic pancreatitis while taking sodium valproate. Necropsy showed widespread vascular disease that may have contributed to the onset of pancreatitis. Previous reports of pancreatitis in children receiving valproic acid are reviewed and although the association is rare, a causal relation between pancreatitis and valproic acid seems to have been established.

The association of sodium valproate with cognitive functions was studied in 29 patients with complex absence seizures. Seventeen patients were on monotherapy and twelve on polypharmacy with sodium valproate. Cognitive functions assessed were attention, speech, visuo-speciat perception, memory and intelligence. Behavioral disturbances were also assessed. Two assessments were made six months apar...

PURPOSE To evaluate the role of ethosuximide, sodium valproate and lamotrigine in children and adolescents with typical absence seizures (AS). METHODS A systematic review of randomized controlled trials that included children or adolescents with typical absence seizures who received treatment with ethosuximide, sodium valproate or lamotrigine. RESULTS Four RCTs fulfilled the inclusion crite...

A patient with chronic depression responded to treatment for her major depressive episodes, but was left with a dysthymia which was eventually relieved by anticonvulsants. Sodium valproate may be of use in a range of affective disorders.

Background: Migraine and other recurrent headaches are considered a major public health concern. Levetiracetam, a broad spectrum anti-epileptic have been used in migraine prophylaxis. Objectives: Assessment the efficacy of levetiracetam on migraine in comparison to sodium valproate. Materials and Methods: This randomized double blind clinical trial was performed on patients with migraine ...

Objective: To study the efficacy and safety of Topiramate versus Sodium Valproate for the Treatment of Bipolar Disorder in Adolescents Methodology: One hundred twenty adolescents (aged 12-18) with an admission diagnosis of bipolar I disorder, manic or mixed episode were enrolled from the Adolescent Ward at Ebn-e-Sina Psychiatric Center of Mashhad University. They were assigned to receive 8 week...

Virtually all anti-epileptic drugs (A.E.n's) can affect mental functions. Greater attention is now being given by epileptologists in assessing cognitive effects of A.E.D's with a view to offer the patients excellent seizure control with least possible negative impact in cognition. Sodium valproate has the advantage of causing minimal dysfunction in cognitive functions as compared to other well ...

Anticonvulsant property of Acorus calamus is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of A. calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole-induced seizures model in rats. On com...

UNLABELLED AIM. This study was designed to examine whether the class I and class IIa histone deacetylase (HDAC) inhibitors, sodium butyrate and sodium valproate alter the expression of human NCOR1 and/or NCOR2 genes coding for N-CoR (nuclear receptor corepressor) and SMRT (silencing mediator for retinoid and thyroid hormone receptors), respectively. METHODS Human leukemia HL-60 cells were tre...